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    Compositions for inducing immune responses
    3.
    发明公开
    Compositions for inducing immune responses 审中-公开
    Zusammensetzungen zur Induzierung von Immunreaktionen

    公开(公告)号：EP2468299A2

    公开(公告)日：2012-06-27

    申请号：EP11196147.0

    申请日：2004-04-30

    申请人： Novartis Vaccines and Diagnostics, Inc.

    发明人： O'Hagan, Derek ,  Singh, Manmohan

    IPC分类号： A61K39/39 ,  A61K45/00 ,  C12Q1/70

    CPC分类号： A61K39/39 ,  A61K2039/55511 ,  A61K2039/55555

    摘要： The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.

    摘要翻译： 本发明尤其提供包含第一抗原，至少两种佐剂的免疫原性组合物，其中第一佐剂包含衍生自聚（丙交酯）和/或聚（丙交酯 - 共 - 乙交酯）的聚合物，其中第二佐剂包含 咪唑并喹啉，其中所述第一抗原包被在所述第一佐剂中并被共冻干或混合，吸附或缀合，以及药学上可接受的赋形剂，其中所述组合物在施用于脊椎动物受试者时引起细胞免疫应答。 本发明还提供了产生免疫原性组合物的方法，在脊椎动物受试者中产生细胞毒性T淋巴细胞（CTL）应答的方法和免疫方法。

    Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
    5.
    发明公开
    Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen 有权
    基于微颗粒含有吸附的类毒素和多糖 - 含有抗原免疫原性组合物

    公开(公告)号：EP2179729A1

    公开(公告)日：2010-04-28

    申请号：EP09075251.0

    申请日：2004-06-02

    申请人： Novartis Vaccines and Diagnostics, Inc.

    发明人： O'Hagan, Derek ,  Singh, Manmohan ,  Kazzaz, Jina

    IPC分类号： A61K9/50 ,  A61K9/16 ,  A61K39/02 ,  A61K39/08 ,  A61K39/12

    CPC分类号： A61K9/1647 ,  A61K9/1641 ,  A61K9/1652 ,  A61K35/74 ,  A61K38/4893 ,  A61K39/05 ,  A61K39/08 ,  A61K39/095 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/6037 ,  A61K2039/6087 ,  A61K2039/6093 ,  C12N2730/10134 ,  C12N2770/32434 ,  C12N2770/32634 ,  Y02A50/466

    摘要： Immunogenic compositions comprising microparticles with adsorbed toxoid antigen and/or polysaccharide-containing antigen are disclosed. The immunogenic microparticle compositions comprising (a) polymer microparticles comprising a biodegradable polymer; (b) an antigen adsorbed to the microparticles selected from (i) a toxoid antigen, such as a tetanus toxoid, a diphtheria toxoid, or a combination thereof, and/or (ii) a polysaccharide containing antigen, such as a Hib polysaccharide antigen, a Hib conjugate antigen comprising polysaccharide and polypeptide regions, a meningococcal polysaccharide antigen, a meningococcal conjugate antigen comprising polysaccharide and polypeptide regions, a pneumococcal polysaccharide antigen, and a pneumococcal conjugate antigen comprising poysaccharide and polypeptide regions or a combination thereof; and (c) a pharmaceutically acceptable excipient.; The biodegradable polymer can be, for example, a polymer selected from a poly(alpha-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and a polycyanoacrylate. Also disclosed are methods of immunization against infection by a pathogenic organisms and methods stimulating immune responses, which comprise administering such compositions to host animals. Methods of producing such microparticle compositions are also disclosed which comprise forming a water-in-oil-in-water emulsion that contains water, organic solvent and biodegradable polymer, followed by removal of the organic solvent from the emulsion to form microparticles, after which toxoid and/or polysaccharide containing antigens are adsorbed on the microparticles.

    Compositions for inducing immune responses
    6.
    发明公开
    Compositions for inducing immune responses 审中-公开
    组合物的免疫应答的诱导

    公开(公告)号：EP2468299A3

    公开(公告)日：2013-04-24

    申请号：EP11196147.0

    申请日：2004-04-30

    申请人： Novartis Vaccines and Diagnostics, Inc.

    发明人： O'Hagan, Derek ,  Singh, Manmohan

    IPC分类号： A61K39/39 ,  A61K45/00 ,  C12Q1/70

    CPC分类号： A61K39/39 ,  A61K2039/55511 ,  A61K2039/55555

    摘要： The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.

    Microparticles with adsorbed polypeptide-containing molecules
    7.
    发明公开
    Microparticles with adsorbed polypeptide-containing molecules 审中-公开
    具有吸附的含多肽分子的微粒

    公开(公告)号：EP2572707A2

    公开(公告)日：2013-03-27

    申请号：EP12178688.3

    申请日：2003-02-20

    申请人： Novartis Vaccines and Diagnostics, Inc.

    发明人： O'Hagan, Derek ,  Singh, Manmohan ,  Kazza, Jina

    IPC分类号： A61K9/14 ,  A61K9/16

    CPC分类号： A61K9/1647 ,  A61K9/1676 ,  A61K9/1694 ,  A61K39/02 ,  A61K39/095 ,  A61K39/39 ,  A61K47/6927 ,  A61K2039/55555 ,  A61K2039/6093 ,  C12N2730/10111 ,  C12N2760/16111

    摘要： Microparticles with adsorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 20,000 Daltons to 70,000 Daltons. Preferred polypeptide-containing molecules are bacterial and viral antigens (including HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens).

    摘要翻译： 公开了在不使用表面活性剂的情况下形成的具有吸附的含多肽分子的微粒，制备这种微粒组合物的方法及其用途。 微粒包含聚合物，例如聚（α-羟基酸），聚羟基丁酸，聚己内酯，聚原酸酯，聚酐等。 优选的聚合物是聚（D，L-丙交酯 - 共 - 乙交酯），更优选具有40:60至60:40的丙交酯/乙交酯摩尔比并且具有20,000道尔顿至70,000道尔顿的分子量的那些。 优选的含有多肽的分子是细菌和病毒抗原（包括HIV抗原，脑膜炎B抗原，链球菌B抗原和甲型流感血凝素抗原）。

    Microemulsions with an adsorbent surface, comprising a microdroplet emulsion
    8.
    发明公开
    Microemulsions with an adsorbent surface, comprising a microdroplet emulsion 审中-公开
    Mikroemulsionen mit einer adsorptionbierendenOberfläche，enthaltend eine Mikrotropfenemulsion

    公开(公告)号：EP2286792A1

    公开(公告)日：2011-02-23

    申请号：EP10179804.9

    申请日：2000-02-09

    申请人： Novartis Vaccines and Diagnostics, Inc.

    发明人： O'Hagan, Derek ,  Ott, Gary S. ,  Donnelly, John ,  Kazzaz, Jina ,  Ugozzoli, Mildred ,  Singh, Manmohan ,  Barackman, John

    IPC分类号： A61K9/00 ,  A61K9/107

    CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

    摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a microdroplet emulsion comprising a metabolisable oil, an emulsifying agent, wherein said emulsifying agent comprises a detergent and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

    摘要翻译： 公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。 微粒包含微滴乳液，其包含可代谢的油，乳化剂，其中所述乳化剂包含洗涤剂，并使用阳离子，阴离子或非离子洗涤剂形成。 微粒表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。 还提供了具有可代谢油和乳化剂的油滴乳液的组合物。 还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。