发明公开
EP2295502A1 Fluorescent perylene derivatives for direct detection of heparin
审中-公开
Fluoreszierende Perylenderivate zur direkten Detektion von Heparin
- 专利标题： Fluorescent perylene derivatives for direct detection of heparin
- 专利标题（中）： Fluoreszierende Perylenderivate zur direkten Detektion von Heparin
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申请号： EP09168292.2申请日： 2009-08-20
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公开(公告)号： EP2295502A1公开(公告)日： 2011-03-16
- 发明人: Kraemer, Roland, Prof. Dr. , Szelke, Helga, Dr. , Harenberg, Job, Prof. Dr. , Poeck, Armin
- 申请人： Ruprecht-Karls-Universität Heidelberg
- 申请人地址： Grabengasse 1 69117 Heidelberg DE
- 专利权人： Ruprecht-Karls-Universität Heidelberg
- 当前专利权人： Ruprecht-Karls-Universität Heidelberg
- 当前专利权人地址： Grabengasse 1 69117 Heidelberg DE
- 代理机构： Elbel, Michaela
- 主分类号： C09B5/62
- IPC分类号： C09B5/62
摘要：
The invention relates to a perylene diimide derivative and to an in vitro method for preparing the same. In addition, the invention relates to a method for detecting heparin in a sample using perylene diimide derivatives, wherein the interaction of the perylene diimide derivative with heparin modulates the intensity of the fluorescent signal of the mixture compared to the solution. The invention also comprises a diagnostic kit for detecting heparin in a sample in vitro, comprising the perylene diimide derivative, as well as the use of the perylene diimide derivative for neutralizing the anticoagulant activity of heparin.
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