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公开(公告)号：EP3609542B1
公开(公告)日：2023-02-22
申请号：EP18716286.2
申请日：2018-04-11
发明人： GRIMM, Dirk , BÖRNER, Kathleen
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公开(公告)号：EP2674186B1
公开(公告)日：2021-12-29
申请号：EP12004399.7
申请日：2012-06-11
发明人： Büchler, Markus , Schneewind, Jörg , Ryzko, Peter , Koeppen, Hannah , Bork, Ulrich , Kenngott, Hannes Götz , Hoffmann, Wolf-Martin , Kaul, Stefan , Weiß, Rainer , Gramlich, Martin , Grafahrend, Dirk
IPC分类号： A61M27/00
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公开(公告)号：EP3356385B1
公开(公告)日：2020-11-11
申请号：EP16778680.5
申请日：2016-09-19
发明人： CARDINALE, Jens , SCHÄFER, Martin , KOPKA, Klaus , EDER, Matthias , BAUDER-WUEST, Ulrike , EISENHUT, Michael , BENESOVA, Martina , HABERKORN, Uwe , GIESEL, Frederik L.
IPC分类号： C07K7/02 , G01N33/68 , G01N33/574 , C07D213/61
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公开(公告)号：EP3063276B1
公开(公告)日：2020-07-15
申请号：EP14793065.5
申请日：2014-10-28
申请人： Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts , Ruprecht-Karls-Universität Heidelberg
IPC分类号： C12N15/113 , A61K31/7088 , A61P3/10
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公开(公告)号：EP3551649A1
公开(公告)日：2019-10-16
申请号：EP17709417.4
申请日：2017-03-06
发明人： GDYNIA, Georg
IPC分类号： C07K14/52
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公开(公告)号：EP2956162B1
公开(公告)日：2019-05-15
申请号：EP14704605.6
申请日：2014-02-17
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公开(公告)号：EP3409794A1
公开(公告)日：2018-12-05
申请号：EP18168242.8
申请日：2014-05-02
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , A61N5/10 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： Provided is a novel method for the early detection and/or discrimination of cancer and anticancer agents for the prevention or early treatment of cancer. In particular, the method relates to the determination of levels of circulating miRNAs in breast cancer patients, both primary and metastatic. Furthermore, kits, devices, pharmaceutical compositions as well as methods related thereto are described.
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公开(公告)号：EP3389691A1
公开(公告)日：2018-10-24
申请号：EP16822406.1
申请日：2016-12-15
发明人： URBAN, Stephan , NI, Yi , MIER, Walter
IPC分类号： A61K38/12 , C07K7/50 , C07K7/64 , C07K14/005 , A61K51/08 , A61K47/50 , A61K51/04 , A61P31/20
摘要： The present invention relates to cyclic NTCP targeting peptides which are preS-derived peptides of hepatitis B virus (HBV). The present invention further relates to pharmaceutical compositions comprising at least one cyclic peptide. The present invention further relates to medical uses of said cyclic peptides and the pharmaceutical compositions, such as in the diagnosis, prevention and/or treatment of a liver disease or condition, and/or in the inhibition of HBV and/or HDV infection. The present invention further relates to methods of diagnosis, prevention and/or treatment of a liver disease or condition and/or the inhibition of HBV and/or HDV infection.
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9.发明公开
公开(公告)号：EP3356385A1
公开(公告)日：2018-08-08
申请号：EP16778680.5
申请日：2016-09-19
发明人： CARDINALE, Jens , SCHÄFER, Martin , KOPKA, Klaus , EDER, Matthias , BAUDER-WUEST, Ulrike , EISENHUT, Michael , BENESOVA, Martina , HABERKORN, Uwe , GIESEL, Frederik L.
IPC分类号： C07K7/02 , A61K38/08 , A61P35/00 , G01N33/68 , A61K38/03 , C07D213/61 , A61K31/465
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.
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公开(公告)号：EP2638026B1
公开(公告)日：2018-07-11
申请号：EP11785376.2
申请日：2011-11-11
发明人： BOUTROS, Michael , MASKEY, Rajendra-Prasad , KOCH, Corinna , FUCHS, Florian , STEINBRINK, Sandra , GILBERT, Daniel
IPC分类号： C07D311/96 , C07D413/04 , C07D491/04 , C07D493/04 , A61K31/352 , A61K31/436 , A61K31/4741 , A61K31/519 , A61P35/00
CPC分类号： C07D311/92 , C07D311/04 , C07D311/96 , C07D413/04 , C07D491/04 , C07D491/052 , C07D493/04
摘要： Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
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