发明公开
- 专利标题: HUMANIZATION OF RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK
- 专利标题(中): 人性化兔抗体使用通用抗体框架
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申请号: EP09768695.0申请日: 2009-06-25
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公开(公告)号: EP2307458A2公开(公告)日: 2011-04-13
- 发明人: BORRAS, Leonardo , URECH, David
- 申请人: ESBATech, an Alcon Biomedical Research Unit LLC
- 申请人地址: Wagistrasse 21 8952 Schlieren CH
- 专利权人: ESBATech, an Alcon Biomedical Research Unit LLC
- 当前专利权人: ESBATech, an Alcon Biomedical Research Unit LLC
- 当前专利权人地址: Wagistrasse 21 8952 Schlieren CH
- 代理机构: Molitor, Julia
- 优先权: US75697P 20080625; US75692P 20080625; US155041P 20090224; US155105P 20090224; CH8322009 20090602
- 国际公布: WO2009155726 20091230
- 主分类号: C07K16/24
- IPC分类号: C07K16/24 ; C07K16/22 ; A61K39/395 ; C12N15/13
摘要:
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
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