公开(公告)号：EP2484447A1

公开(公告)日：2012-08-08

申请号：EP11000970.1

申请日：2011-02-07

申请人： Biocartis SA

发明人： Demierre, Nicolas

IPC分类号： B01L3/00

CPC分类号： G01N21/6486 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00558 ,  B01J2219/0056 ,  B01J2219/00576 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/021 ,  B01L2300/0832 ,  G01N33/54313

摘要： The present invention relates to an encoded microcarrier (2) comprising a readable code attached to it for identification, said encoded microcarrier (2) comprising a body (3) having at least a detection surface (6) to detect a chemical and/or biological reaction, the microcarrier further comprising at least a spacing element (9) projecting from the body (3) and shaped to ensure that, when the encoded microcarrier (2) is laid on a flat plane with the detection surface (6) facing said flat plane, a gap exists between said flat plane and the detection surface (6). The invention also relates to an assay device designed to use a plurality of said encoded microcarriers (2) to perform assays. The invention relates finally to a method for monitoring a chemical or biological reaction.

摘要翻译： 本发明涉及一种编码的微载体（2），包括附于其上的可读代码进行识别，所述编码微载体（2）包括具有至少检测表面（6）的主体（3），以检测化学和/或生物 所述微载体还包括至少一个从所述主体（3）突出的间隔元件（9）并成形为确保当所述编码的微载体（2）放置在平面上时，所述检测表面（6）面向所述平面 在所述平面与检测面（6）之间存在间隙。 本发明还涉及被设计为使用多个所述编码的微载体（2）进行测定的测定装置。 本发明最终涉及用于监测化学或生物反应的方法。

公开(公告)号：EP2314622A1

公开(公告)日：2011-04-27

申请号：EP10010455.3

申请日：2003-05-21

申请人： ESBATech, an Alcon Biomedical Research Unit LLC

发明人： Tissot, Kathrin ,  Ewert, Stefan ,  Auf der Maur, Adrian ,  Barberis, Alcide ,  Escher, Dominik

IPC分类号： C07K16/18 ,  C12N15/09 ,  A61K48/00

CPC分类号： C07K16/00 ,  A61K48/00 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/80 ,  C07K2317/82 ,  C07K2317/94 ,  G01N33/6857

摘要： Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.

摘要翻译： 提供了组合物，其可以被用作用于创建非常稳定的和可溶的单链Fv抗体片段的框架。 这些框架已被选定为细胞内的性能，并且因此非常适合用于创建scFv抗体片段或scFv抗体文库的为其中的稳定性和溶解性的限制因素为抗体片段，：如在细胞的还原环境的应用程序的性能。 因此Web框架可以被用于识别高度保守的残基，并且其证明增强的溶解性和稳定性的共有序列。

公开(公告)号：EP2307457A2

公开(公告)日：2011-04-13

申请号：EP09768692.7

申请日：2009-06-25

申请人： ESBATech, an Alcon Biomedical Research Unit LLC

发明人： BORRAS, Leonardo ,  GUNDE, Tea ,  URECH, David

IPC分类号： C07K16/24 ,  A61K39/395 ,  C12N15/13

CPC分类号： C07K16/241 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92

摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.

公开(公告)号：EP2409767A1

公开(公告)日：2012-01-25

申请号：EP11005261.0

申请日：2006-06-16

申请人： Biocartis SA

发明人： Van Haag, Chris ,  Jongerius, Michiel ,  Schaefer, Danny G.A. ,  Van den Bijgaart, Adrianus ,  De Gier, Ronald ,  De Jong, Michiel ,  Pross, Gerhard ,  Bacher, Johannes ,  Boos, Andreas ,  Luedke, Gerd ,  Seher, Jens-Peter

IPC分类号： B01L3/00 ,  G01N1/28 ,  G01N21/76 ,  G01N35/00 ,  G01N33/487 ,  G01N21/64 ,  C12Q1/68

CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/545 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/02 ,  B01L2300/087 ,  B01L2300/1805 ,  G01N21/6428 ,  G01N35/00069 ,  G01N2035/00158

摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.

摘要翻译： 公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。 墨盒包括通用部件和可以连接到通用部件的一个或多个单独的应用特定部件。 还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。 该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

公开(公告)号：EP2368574A1

公开(公告)日：2011-09-28

申请号：EP10011428.9

申请日：2004-03-15

申请人： ANERGIS SA

发明人： Corthesy, Blaise ,  Spertini, Francois

IPC分类号： A61K39/35 ,  A61K39/36 ,  A61P37/08 ,  C07K14/415 ,  C07K14/435

CPC分类号： A61K38/168 ,  A61K39/35 ,  C07K14/415 ,  C07K14/43531 ,  C07K14/43563 ,  C07K14/43572

摘要： The present invention relates generally to methods for generating compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen.

摘要翻译： 本发明一般涉及产生为变应原特异性免疫疗法设计的组合物的方法。 组合物包括连续重叠的肽片段，其一起形成变应原的完整氨基酸序列。

公开(公告)号：EP2367633A1

公开(公告)日：2011-09-28

申请号：EP09795681.7

申请日：2009-12-23

申请人： Biocartis SA

发明人： DEMIERRE, Nicolas ,  NADER, Donzel ,  GIL, José ,  RENAUD, Philippe

IPC分类号： B01L3/00 ,  B01J19/00 ,  G01N33/543

CPC分类号： G01N33/54373 ,  B01J2219/005 ,  B01J2219/00556 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0654 ,  B01L2400/0424 ,  B01L2400/043 ,  B01L2400/0487

摘要： The invention provides a multiplexed assay device comprising a reaction chamber and several sets of encoded microcarriers 2 wherein the reaction chamber is a microchannel 1 and wherein the longitudinal movement of the microcarriers 2 is restricted and wherein the microcarriers 2 have a shape in relation to the geometry of the microchannel 1 such that at least two can stand side by side in the microchannel 1 without touching each other and without touching the perimeter of the microchannel 1 and are preferably observable in the reaction chamber. Moreover, the invention provides a method for performing multiplexed assay based on microcarriers 2 that improves mass transfer, simplifies the preparation and the execution of the assay and facilitates readout of biological reactions and identity of microcarriers 2.

公开(公告)号：EP2307458A2

公开(公告)日：2011-04-13

申请号：EP09768695.0

申请日：2009-06-25

申请人： ESBATech, an Alcon Biomedical Research Unit LLC

发明人： BORRAS, Leonardo ,  URECH, David

IPC分类号： C07K16/24 ,  C07K16/22 ,  A61K39/395 ,  C12N15/13

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6877 ,  C07K16/22 ,  C07K16/241 ,  C07K16/30 ,  C07K16/465 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

摘要： The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.

摘要翻译： 本发明涉及到通用抗体受体构架和用于接枝非人抗体，E. G.，兔抗体，使用通用抗体受体构架的方法。 通过本发明的方法产生的抗体可用于多种诊断和治疗应用。

公开(公告)号：EP2421544A1

公开(公告)日：2012-02-29

申请号：EP10766735.4

申请日：2010-03-25

申请人： Menashe, Ofir

发明人： Menashe, Ofir

IPC分类号： A61K35/74 ,  C12N1/20

CPC分类号： A61K9/50 ,  A61K35/66 ,  A61K35/74 ,  A61K38/00 ,  B09C1/10 ,  C02F3/106 ,  C02F3/107 ,  C02F3/322 ,  C02F3/342 ,  C02F3/348 ,  C12N11/04 ,  C12N11/08 ,  C12P21/02 ,  Y02W10/15

摘要： A particle is disclosed. The particle comprising: (i) at least one inner core which comprises a solid matrix of nutrients for microorganism growth; (ii) an inner membrane being fabricated from a water-soluble polymer, the inner membrane surrounding the inner core and a population of dried microorganisms; and (iii) an outer porous membrane surrounding the inner membrane, the outer porous membrane being insoluble in water. Methods of generating same, propagating microorganisms within and uses of same are also disclosed.

公开(公告)号：EP2392596A2

公开(公告)日：2011-12-07

申请号：EP10010030.4

申请日：2000-12-18

申请人： ESBATech, an Alcon Biomedical Research Unit LLC

发明人： Auf der Maur, Adrian ,  Barberis, Alcide ,  Escher, Dominik

IPC分类号： C07K16/00 ,  C12N15/10 ,  C12N15/13 ,  A61K39/395 ,  C07K19/00 ,  G01N33/577

CPC分类号： C07K16/005 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/14 ,  C07K2317/622 ,  C07K2317/80 ,  C07K2318/10 ,  C07K2319/00 ,  C12N15/1055 ,  C12N15/1093

摘要： Methods for the generation of a CDR library with a defined framework that is stable and soluble in a reducing environment are described as well as thus obtained library of intrabodies.

摘要翻译： 对于CDR库定义的框架的生成方法所做的就是稳定，易溶于还原环境中被描述，以及细胞内抗体由此获得库。

公开(公告)号：EP2321644A1

公开(公告)日：2011-05-18

申请号：EP09778306.2

申请日：2009-09-03

申请人： Ernst-Moritz-Arndt-Universität Greifswald ,  Drk Blutspendedienst West GmbH

发明人： GREINACHER, Andreas ,  WESCHE, Jan ,  BUX, Jürgen ,  REIL, Angelika

IPC分类号： G01N33/50

CPC分类号： C12Q1/6881 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6854 ,  G01N33/6893 ,  G01N2800/12 ,  G01N2800/245

摘要： The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids in a sample of a biological tissue intended for transplantation.