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公开(公告)号：EP2321354B2
公开(公告)日：2019-11-20
申请号：EP10705086.6
申请日：2010-02-22
IPC分类号： C07K16/28 , C12N5/0781 , C12N15/13 , G01N33/537
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公开(公告)号：EP2947095B1
公开(公告)日：2019-10-02
申请号：EP15160739.7
申请日：2003-05-21
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公开(公告)号：EP3498731A1
公开(公告)日：2019-06-19
申请号：EP18204324.0
申请日：2010-12-21
发明人： Borras, Leonardo , Gunde, Tea , Urech, David
IPC分类号： C07K16/00
摘要： A method for decreasing the immunogenicity of antibody variable domains is disclosed.
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4.发明授权Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same 有权在细胞内空间具有改善的稳定性和Immunoglobulinrahmen识别方法
公开(公告)号：EP2332989B1
公开(公告)日：2015-04-01
申请号：EP10009857.3
申请日：2003-05-21
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
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5.发明公开Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same 有权在细胞内空间具有改善的稳定性和Immunoglobulinrahmen识别方法
公开(公告)号：EP2332989A1
公开(公告)日：2011-06-15
申请号：EP10009857.3
申请日：2003-05-21
CPC分类号： C07K16/00 , A61K48/00 , C07K2317/21 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/80 , C07K2317/82 , C07K2317/94 , G01N33/6857
摘要： A single chain variable framework has been selected for intracellular performance which may be used in diagnostic and therapeutic applications, target validation and gene therapy.
摘要翻译： 单链可变框架已被选择为可在诊断和治疗应用，靶标确认和基因治疗中使用的细胞内的性能。
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公开(公告)号：EP2303230A2
公开(公告)日：2011-04-06
申请号：EP09775745.4
申请日：2009-07-10
CPC分类号： A61K47/183 , A61K9/0043 , A61K9/08 , A61K39/3955 , A61K2039/505 , A61K2039/543 , C07K16/241 , C07K2317/24 , C07K2317/622 , Y02P20/55 , A61K2300/00
摘要： The invention provides compositions and methods that enhance the delivery of large macromolecules (i.e., greater than 10kDa), such as antigen-binding polypeptides, across tight junctions. Such methods and compositions are particularly useful for delivering therapeutic antigen-binding polypeptides to the CNS, via intranasal administration, for the treatment of neurological disorders.
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公开(公告)号：EP2307457B1
公开(公告)日：2018-06-13
申请号：EP09768692.7
申请日：2009-06-25
发明人： BORRAS, Leonardo , GUNDE, Tea , URECH, David
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13
CPC分类号： C07K16/241 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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公开(公告)号：EP3260465A1
公开(公告)日：2017-12-27
申请号：EP17167592.9
申请日：2006-06-06
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFa, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFa, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFa-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
摘要翻译： 本发明涉及对TNFα特异的特别稳定和可溶的scFv抗体和Fab片段，其包含针对TNFα的稳定性，溶解性，体外和体内结合以及低免疫原性而优化的特定轻链和重链序列。 所述抗体被设计用于诊断和/或治疗TNFα相关病症。 还公开了用于表达本发明重组抗体的核酸，载体和宿主细胞，分离它们的方法以及所述抗体在药物中的用途。
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公开(公告)号：EP3216803A1
公开(公告)日：2017-09-13
申请号：EP17151756.8
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David , GUNDE, Tea
IPC分类号： C07K16/22 , A61K39/395
摘要： The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
摘要翻译： 本发明涉及包含来自兔单克隆抗体的CDR的可溶且稳定的抗VEGF免疫结合剂。 所述抗体被设计用于诊断和/或治疗VEGF介导的病症。 还公开了用于表达本发明的重组抗体的杂交瘤，核酸，载体和宿主细胞，分离它们的方法以及所述抗体在医学中的用途。
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10.发明授权Intrabodies ScFv with defined framework that is stable in a reducing environment 有权ScFv的胞内抗体与定义的结构（“框架”），这是在还原性环境中是稳定
公开(公告)号：EP1479694B1
公开(公告)日：2016-10-26
申请号：EP04017280.1
申请日：2000-12-18
IPC分类号： C07K16/00 , C12N15/10 , C12N15/13 , A61K39/395 , C07K19/00 , G01N33/577
CPC分类号： C07K16/005 , A61K2039/505 , C07K16/00 , C07K16/14 , C07K2317/622 , C07K2317/80 , C07K2318/10 , C07K2319/00 , C12N15/1055 , C12N15/1093
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