发明公开
- 专利标题： CYCLOHEXENYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
- 专利标题（中）： 环丙基胆碱酯酶调节蛋白激酶
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申请号： EP09790359.5申请日： 2009-07-14
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公开(公告)号： EP2318352A2公开(公告)日： 2011-05-11
- 发明人: CARTER, Percy, H. , BROWN, Gregory, D. , DE LUCCA, George, V. , BATT, Douglas, G. , LIU, Rui-Qin , QIU, Feng
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road P.O. Box 4000 Princeton NJ 08543-4000 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road P.O. Box 4000 Princeton NJ 08543-4000 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US81180P 20080716
- 国际公布： WO2010009068 20100121
- 主分类号： C07C61/15
- IPC分类号： C07C61/15 ; C07C61/28 ; C07C61/39 ; C07C61/40 ; C07C62/32 ; C07C62/34 ; C07C233/47 ; C07C311/51 ; A61K31/18 ; A61K31/192 ; A61P19/02 ; A61P9/12 ; A61P11/06 ; A61P31/18
摘要：
The present application describes modulators of MCP-1 or CCR-2 of formula,(I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R
1 , R
2 , R
4 and R
6 , are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula, (I) are disclosed.
1 , R
2 , R
4 and R
6 , are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula, (I) are disclosed.
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