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103 条记录 (耗时 0.022 秒)

    TETRAHYDRONAPHTHYL AND CYCLOPROPYL SUBSTITUTED 1,3-BUTADIENES HAVING RETINOID-LIKE ACTIVITY
    6.
    发明授权
    TETRAHYDRONAPHTHYL AND CYCLOPROPYL SUBSTITUTED 1,3-BUTADIENES HAVING RETINOID-LIKE ACTIVITY 失效
    维A酸酶活性并且TETRAHYDRONAPHTYL-环丙基取代的1,3-丁二烯

    公开(公告)号：EP0699178B1

    公开(公告)日：1998-06-24

    申请号：EP94916645.8

    申请日：1994-05-03

    申请人： Allergan, Inc.

    发明人： CHANDRARATNA, Roshantha, A.

    IPC分类号： C07C61/39 ,  A61K31/19 ,  C07C61/40

    CPC分类号： C07F9/5428 ,  C07C17/16 ,  C07C33/30 ,  C07C45/292 ,  C07C45/46 ,  C07C49/792 ,  C07C61/39 ,  C07C69/743 ,  C07C19/01

    摘要： Compounds of formula (I) wherein m is 1-4; R1-R4 independdently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R6 is hydrogen, lower alkyl, Cl, Br, I, OR11, SR11, OCOR11, SCOR11, NH2, NHR11, N(R11)2, NHCOR11 or NR11-COR11; R20 is independently hydrogen or lower alkyl; A is (CH2)n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR7, CR7(OR12)2, or CR7OR13O, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R11 is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is divalent alkyl radical of 2-5 carbons, have retinoid-like biological activity.