- 专利标题： Spatially-defined macrocyclic compounds useful for drug discovery
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申请号： EP10011014.7申请日： 2004-08-02
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公开(公告)号： EP2319859A3公开(公告)日： 2011-12-21
- 发明人: Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Ramaseshan, Mahesh , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Hoveyda, Hamid R. , Beaubien, Sylvie , Peterson, Mark L.
- 申请人： Tranzyme Pharma Inc.
- 申请人地址： 3991 12e Avenue Nord IPS Sherbrooke QC J1H 5N4 CA
- 专利权人： Tranzyme Pharma Inc.
- 当前专利权人： Tranzyme Pharma Inc.
- 当前专利权人地址： 3991 12e Avenue Nord IPS Sherbrooke QC J1H 5N4 CA
- 代理机构： McNab, Donald C.
- 优先权： US491248P 20030731
- 主分类号： C07K5/00
- IPC分类号： C07K5/00 ; C07K5/08 ; C07K1/04 ; C07K5/12
摘要：
Spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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