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1.发明公开Spatially-defined macrocyclic compounds useful for drug discovery 有权on n n n n n n n n n n n n n n n n n n
公开(公告)号：EP2316846A2
公开(公告)日：2011-05-04
申请号：EP10011035.2
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Beaubien, Sylvie , Peterson, Mark L. , Ramaseshan, Mahesh , Hoveyda, Hamid R.
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了包含特定构象控制元件的新的空间定义的大环化合物。 然后使用这些大环的文库来选择一个或多个表现出与特定生物靶特异性相互作用的大环物种。 特别地，根据本发明的化合物公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号：EP2210612A3
公开(公告)日：2010-11-24
申请号：EP10001568.4
申请日：2004-06-18
申请人： Tranzyme Pharma Inc.
发明人： Marsault, Eric , Benakli, Kamel , Peterson, Mark , Beaubien, Sylvie , St-Louis, Carl , Ouellet, Luc , Beauchemin, Sophie , Hoveyda, Hamid
IPC分类号： A61K38/22 , C07K5/08 , C07C13/00 , C07C15/00 , C07D213/00
CPC分类号： C07C213/08 , A61K38/12 , A61K38/2214 , C07C41/18 , C07C67/343 , C07D273/00 , C07D413/06 , C07D498/04 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The invention provides a first group of intermediates useful in the manufacture of conformationally-defined macrocyclic compounds, a method for making some of these and a second group of intermediate compounds prepared in this method, use of the first group of intermediates in the manufacture of conformationally-defined macrocyclic compounds and a method of so manufacturing, and conformationally-defined macrocyclic compounds made from the first group of intermediates.
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公开(公告)号：EP2319859A3
公开(公告)日：2011-12-21
申请号：EP10011014.7
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Ramaseshan, Mahesh , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Hoveyda, Hamid R. , Beaubien, Sylvie , Peterson, Mark L.
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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4.发明公开
公开(公告)号：EP2210612A2
公开(公告)日：2010-07-28
申请号：EP10001568.4
申请日：2004-06-18
申请人： Tranzyme Pharma Inc.
发明人： Marsault, Eric , Benakli, Kamel , Peterson, Mark , Beaubien, Sylvie , St-Louis, Carl , Ouellet, Luc , Beauchemin, Sophie , Hoveyda, Hamid
IPC分类号： A61K38/22 , C07K5/08 , C07C13/00 , C07C15/00 , C07D213/00
CPC分类号： C07C213/08 , A61K38/12 , A61K38/2214 , C07C41/18 , C07C67/343 , C07D273/00 , C07D413/06 , C07D498/04 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The invention provides a first group of intermediates useful in the manufacture of conformationally-defined macrocyclic compounds, a method for making some of these and a second group of intermediate compounds prepared in this method, use of the first group of intermediates in the manufacture of conformationally-defined macrocyclic compounds and a method of so manufacturing, and conformationally-defined macrocyclic compounds made from the first group of intermediates.
摘要翻译： 本发明提供了可用于制造构象定义的大环化合物的第一组中间体，用于制备其中一些的方法和在该方法中制备的第二组中间体化合物，第一组中间体在制造构象中的用途 定义的大环化合物和由第一组中间体制备的方法，以及构象定义的大环化合物。
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5.发明公开Spatially-defined macrocyclic compounds useful for drug discovery 有权on n n n n n n n n n n n n n n n n n n
公开(公告)号：EP2316846A3
公开(公告)日：2012-04-04
申请号：EP10011035.2
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Beaubien, Sylvie , Peterson, Mark L. , Ramaseshan, Mahesh , Hoveyda, Hamid R.
IPC分类号： C07K5/00 , C07K5/08 , C07K1/04 , C07K5/12 , C07D263/32 , C07D277/24 , C07D277/28
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了含特定构象控制元素的空间定义的大环化合物。 然后使用这些大环的文库来选择一个或多个表现出与特定生物靶特异性相互作用的大环物种。 特别地，根据本发明的化合物公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号：EP2319859B1
公开(公告)日：2013-03-27
申请号：EP10011014.7
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Ramaseshan, Mahesh , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Hoveyda, Hamid R. , Beaubien, Sylvie , Peterson, Mark L.
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
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公开(公告)号：EP2319859A2
公开(公告)日：2011-05-11
申请号：EP10011014.7
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Ramaseshan, Mahesh , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Hoveyda, Hamid R. , Beaubien, Sylvie , Peterson, Mark L.
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了含有特定构象控制元件的空间限定的大环化合物。 然后使用这些大环化合物的文库来选择与特定生物学目标呈现特异性相互作用的一种或多种大环化合物物种。 具体而言，公开了本发明的化合物作为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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