发明公开
EP2356113A1 HETEROCYCLISCH SUBSTITUIERTE ARYL-VERBINDUNGEN ALS HIF-INHIBITOREN
有权
杂环取代的芳基化合物AS HIF抑制剂
- 专利标题： HETEROCYCLISCH SUBSTITUIERTE ARYL-VERBINDUNGEN ALS HIF-INHIBITOREN
- 专利标题（英）： Heterocyclically substituted aryl compounds as hif inhibitors
- 专利标题（中）： 杂环取代的芳基化合物AS HIF抑制剂
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申请号： EP09744351.9申请日： 2009-10-31
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公开(公告)号： EP2356113A1公开(公告)日： 2011-08-17
- 发明人: HÄRTER, Michael , BECK, Hartmut , ELLINGHAUS, Peter , BERHOERSTER, Kerstin , GRESCHAT, Susanne , THIERAUCH, Karl-Heinz , SÜSSMEIER, Frank
- 申请人： Bayer Schering Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 优先权： DE102008057343 20081114; DE102009041242 20090911
- 国际公布： WO2010054763 20100520
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; C07D413/14 ; C07D471/08 ; C07D487/08 ; A61K31/4245 ; A61K31/454 ; A61K31/4545 ; A61K31/497 ; A61P35/00
摘要：
The present application relates to novel heterocyclically substituted aryl compounds, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for production of medicaments for treatment and/or prevention of disorders, especially for treatment and/or prevention of hyperproliferative and angiogenic disorders, and those disorders which arise as a result of a metabolic adaptation to hypoxic states. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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