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1.发明公开SUBSTITUIERTE DIHYDROPYRAZOLONE ALS HEMMER DER HIF-PROLYL-4-HYDROXYLASE 有权代入为HIF脯氨酰4-羟化酶抑制剂dihydropyrazolones
公开(公告)号：EP2265602A1
公开(公告)日：2010-12-29
申请号：EP09733899.0
申请日：2009-04-11
发明人： JESKE, Mario , FLAMME, Ingo , STOLL, Friederike , BECK, Hartmut , AKBABA, Metin
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , A61K31/506 , A61K31/5355 , A61K31/553 , A61P9/00 , A61P13/12 , A61P7/06
CPC分类号： C07D403/14 , C07D401/14 , C07D413/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, to methods for the preparation thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for the production of medicines for the treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases, kidney diseases, and for the promotion of wound healing.
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2.发明公开
公开(公告)号：EP2356112A1
公开(公告)日：2011-08-17
申请号：EP09744089.5
申请日：2009-10-31
发明人： HÄRTER, Michael , BECK, Hartmut , ELLINGHAUS, Peter , BERHOERSTER, Kerstin , GRESCHAT, Susanne , THIERAUCH, Karl-Heinz , SÜSSMEIER, Frank
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/435 , A61P35/00 , A61P3/00
CPC分类号： C07D413/04 , C07D413/14
摘要： The present application relates to novel substituted aryl compounds, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for production of medicaments for treatment and/or prevention of disorders, especially for treatment and/or prevention of hyperproliferative and angiogenic disorders, and those disorders which arise as a result of a metabolic adaptation to hypoxic states. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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3.发明公开NOVEL SULPHOXIMINE-SUBSTITUTED QUINAZOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS 审中-公开新SULPHOXIMIN - 取代喹唑啉和喹唑啉衍生物作为激酶抑制剂
公开(公告)号：EP2152672A1
公开(公告)日：2010-02-17
申请号：EP08749502.4
申请日：2008-05-23
发明人： EIS, Knut , PRIEN, Olaf , LUECKING, Ulrich , GUENTHER, Judith , ZOPF, Dieter , BROHM, Dirk , VÖHRINGER, Verena , WOLTERING, Elisabeth , BECK, Hartmut , LOBELL, Mario , LI, Volkhart, Min-Jian , GRESCHAT, Susanne
IPC分类号： C07D215/233 , C07D215/42 , C07D215/44 , C07D239/94 , C07D401/12 , A61K31/4706 , A61K31/4709 , A61K31/47 , A61P35/00 , A61P25/28
CPC分类号： C07D239/86 , C07D215/44 , C07D409/04
摘要： The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
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公开(公告)号：EP2356114A1
公开(公告)日：2011-08-17
申请号：EP09755840.7
申请日：2009-10-31
发明人： HÄRTER, Michael , BECK, Hartmut , ELLINGHAUS, Peter , BERHOERSTER, Kerstin , GRESCHAT, Susanne , THIERAUCH, Karl-Heinz
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , A61K31/4245 , A61K31/435 , A61P3/00 , A61P35/00
CPC分类号： C07D417/14 , C07D413/04 , C07D413/14
摘要： The present application relates to novel aminoalkyl-substituted aryl compounds, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for production of medicaments for treatment and/or prevention of disorders, especially for treatment and/or prevention of hyperproliferative and angiogenic disorders, and those disorders which arise as a result of a metabolic adaptation to hypoxic states. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：EP2356113A1
公开(公告)日：2011-08-17
申请号：EP09744351.9
申请日：2009-10-31
发明人： HÄRTER, Michael , BECK, Hartmut , ELLINGHAUS, Peter , BERHOERSTER, Kerstin , GRESCHAT, Susanne , THIERAUCH, Karl-Heinz , SÜSSMEIER, Frank
IPC分类号： C07D413/04 , C07D413/14 , C07D471/08 , C07D487/08 , A61K31/4245 , A61K31/454 , A61K31/4545 , A61K31/497 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D413/04 , C07D413/14 , C07D471/08 , C07D487/08
摘要： The present application relates to novel heterocyclically substituted aryl compounds, to processes for preparation thereof, to the use thereof for treatment and/or prevention of disorders and to the use thereof for production of medicaments for treatment and/or prevention of disorders, especially for treatment and/or prevention of hyperproliferative and angiogenic disorders, and those disorders which arise as a result of a metabolic adaptation to hypoxic states. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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6.发明公开SUBSTITUIERTE BICYCLISCHE HETEROARYLVERBINDUNGEN ZUR BEHANDLUNG KARDIOVASKULÄRER ERKRANKUNGEN 审中-公开取代的双环杂芳基化合物治疗心血管疾病
公开(公告)号：EP2167482A1
公开(公告)日：2010-03-31
申请号：EP08758972.7
申请日：2008-06-03
发明人： LAMPE, Thomas , KAST, Raimund , BECK, Hartmut , STOLL, Friedericke , BECKER, Eva-Maria , JESKE, Mario , SCHUHMACHER , Joachim
IPC分类号： C07D307/80 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/343 , A61K31/34 , A61K31/381 , A61P9/00
CPC分类号： C07D495/04 , C07D307/80 , C07D487/04 , C07D491/048
摘要： The present application relates to novel substituted bicyclic heteroaryl compounds, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases, and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, particularly for the treatment and/or prophylaxis of cardiovascular diseases.
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公开(公告)号：EP2158206A1
公开(公告)日：2010-03-03
申请号：EP08758971.9
申请日：2008-06-03
发明人： LAMPE, Thomas , KAST, Raimund , JESKE, Mario , STOLL, Friederike , SCHUHMACHER, Joachim , BECKER, Eva-Maria , BECK, Hartmut
IPC分类号： C07D491/048 , A61K31/519 , A61P9/00
CPC分类号： C07D491/048
摘要： The invention relates to novel substituted furopyrimidine derivatives, to a method for their production, to their use for the treatment and/or prophylaxis of diseases and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
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8.发明授权NEUE, ZYKLISCH SUBSTITUIERTE FUROPYRIMIDIN-DERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON KARDIOVASKULÄREN ERKRANKUNGEN 有权新的环状结构的取代furopyrimidine衍生物及其用于治疗心血管疾病治疗
公开(公告)号：EP1966218B1
公开(公告)日：2010-07-14
申请号：EP06840964.8
申请日：2006-12-08
发明人： LAMPE, Thomas , BECKER, Eva-Maria , KAST, Raimund , BECK, Hartmut , JESKE, Mario , SCHUHMACHER, Joachim , STOLL, Friederike , KLEIN, Martina , AKBABA, Metin , KNORR, Andreas , STASCH, Johannes-Peter , BÄRFACKER, Lars , HILLISCH, Alexander , KARIG, Gunter , MEININGHAUS, Mark , SCHLEMMER, Karl-Heinz , SCHOHE-LOOP, Rudolf
IPC分类号： C07D491/04 , A61K31/519 , A61P9/00
CPC分类号： C07D491/04
摘要： The invention relates to novel, cyclic substituted furopyrimidine derivatives represented by formula (I), to methods for the production thereof, to the use thereof for treating and/or for the prophylaxis of illnesses and to the use thereof for producing medicaments for treating and/or for the prophylaxis of diseases, in particular for treating and/or for the prophylaxis of cardiovascular diseases.
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9.发明公开INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 审中-公开缺氧诱导因子，用于治疗和过度增生性血管生成相关的疾病抑制剂（HIF）
公开(公告)号：EP2148877A2
公开(公告)日：2010-02-03
申请号：EP08758408.2
申请日：2008-05-08
发明人： BOYER, Stephen , HÄRTER, Michael , WICKENS, Philip , PATEL, Manoj , KUMARASINGHE, Ellalahewage, Sathyajith , BHARGAVA, Ajay, Kumar , THIERAUCH, Karl-Heinz , BECK, Hartmut , GRESCHAT, Susanne , ELLINGHAUS, Peter , PAULUS, Patrick , HESS-STUMPP, Holger
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/04 , A61K31/4245 , A61P35/00
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
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