发明授权
- 专利标题： Method of producing proteins comprising unnatural amino acid
- 专利标题（中）： 用于生产蛋白与非天然氨基酸的方法
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申请号： EP11165139.4申请日： 2004-04-16
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公开(公告)号： EP2392923B1公开(公告)日： 2014-05-21
- 发明人: Deiters, Alexander , Cropp, Ashton T. , Chin, Jason W. , Anderson, Christopher J. , Schultz, Peter G.
- 申请人： The Scripps Research Institute
- 申请人地址： 10550 North Torrey Pines Road La Jolla, CA 92037 US
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： 10550 North Torrey Pines Road La Jolla, CA 92037 US
- 代理机构： Casley, Christopher Stuart
- 优先权： US479931P 20030618; US493014P 20030805; US496548P 20030819
- 主分类号： C07C269/06
- IPC分类号： C07C269/06 ; C07C311/41 ; C07C227/22 ; C07C229/36 ; C07K1/107 ; C07K1/13 ; C09B11/08 ; C09B57/00 ; C07K14/01 ; C07K14/00 ; C12P21/02 ; C12N9/00 ; C12N15/67 ; C12P17/04 ; C07K16/18 ; G01N33/532
摘要：
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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