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1.发明公开Orthogonal translation components for the in vivo incorporation of unnatural amino acids 有权对非天然氨基酸的体内掺入正交翻译组分
公开(公告)号：EP2383340A3
公开(公告)日：2012-03-21
申请号：EP11165007.3
申请日：2005-10-27
发明人： Alfonta, Lital , Schultz, Peter , Zeng, Huaqiang , Xie, Jianming , Wu, Ning , Wang, Jiangyun , Tsao, Meng-lin , Summerer, Daniel , Groff, Dan , Deiters, Alexander , Chittuluru, Jonathan, R. , Seyedsayamdost, Mohammad R. , Turner, James
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E.coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
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2.发明授权Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids 有权氨酰-tRNA合成酶的tRNA的氨酰化具有非天然氨基酸
公开(公告)号：EP2410331B1
公开(公告)日：2015-09-23
申请号：EP11165160.0
申请日：2004-04-16
发明人： Deiters, Alexander , Cropp, Ashton T. , Chin, Jason W. , Anderson, Christopher J. , Schultz, Peter G.
IPC分类号： C07C269/06 , C07C311/41
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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3.发明公开Method of prodcucing proteins comprising unnatural amino acid 有权Methode zur Herstellung von Proteinen mitunnatürlichenAminosäuren
公开(公告)号：EP2392923A1
公开(公告)日：2011-12-07
申请号：EP11165139.4
申请日：2004-04-16
发明人： Deiters, Alexander , Cropp, Ashton T. , Chin, Jason W. , Anderson, Christopher J. , Schultz, Peter G.
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供了用于产生扩增真核细胞中遗传编码氨基酸数量的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：EP2378288A1
公开(公告)日：2011-10-19
申请号：EP11163742.7
申请日：2004-04-16
发明人： Deiters, Alexander , Cropp, Ashton, T. , Chin, Jason, W. , Anderson, Christopher, J. , Schultz, Peter, G.
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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5.发明授权Unnatural reactive amino acid genetic code additions 有权Hinzufügungenvon genetischen代码vonunnatürlichenreaktivenAminosäuren
公开(公告)号：EP2378288B1
公开(公告)日：2015-09-09
申请号：EP11163742.7
申请日：2004-04-16
发明人： Deiters, Alexander , Cropp, Ashton, T. , Chin, Jason, W. , Anderson, Christopher, J. , Schultz, Peter, G.
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供了用于产生扩增真核细胞中遗传编码氨基酸数量的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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6.发明授权Orthogonal translation components for the in vivo incorporation of unnatural amino acids 有权对非天然氨基酸的体内掺入正交翻译组分
公开(公告)号：EP2380982B1
公开(公告)日：2014-07-16
申请号：EP11164983.6
申请日：2005-10-27
发明人： Alfonta, Lital , Schultz, Peter , Zeng, Huaqiang , Xie, Jianming , Wu, Ning , Wang, Jiangyun , Tsao, Meng-lin , Summerer, Daniel , Groff, Dan , Deiters, Alexander , Chittuluru, Jonathan, R. , Seyedsayamdost, Mohammad R. , Turner, James
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
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7.发明公开Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids 有权氨酰基-tRNA合成酶zur Aminoacylierung von tRNA mitunnatürlichenAminosäuren
公开(公告)号：EP2410331A1
公开(公告)日：2012-01-25
申请号：EP11165160.0
申请日：2004-04-16
发明人： Deiters, Alexander , Cropp, Ashton T. , Chin, Jason W. , Anderson, Christopher J. , Schultz, Peter G.
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供了用于产生扩增真核细胞中遗传编码氨基酸数量的翻译组分的组合物和方法。 组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。 还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。
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公开(公告)号：EP2793027B1
公开(公告)日：2019-11-13
申请号：EP14171211.7
申请日：2004-04-16
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公开(公告)号：EP2793027A1
公开(公告)日：2014-10-22
申请号：EP14171211.7
申请日：2004-04-16
发明人： Deiters, Alexander , Cropp, Ashton. T. , Chin, Jason W , Anderson, Christopher J. , Schultz, Peter, G.
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译： 本发明提供了用于产生扩增真核细胞中遗传编码的氨基酸数量的翻译组分的组合物和方法。 组件包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。 还提供了蛋白质和在真核细胞中用非天然氨基酸生产蛋白质的方法。
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公开(公告)号：EP2392923B1
公开(公告)日：2014-05-21
申请号：EP11165139.4
申请日：2004-04-16
发明人： Deiters, Alexander , Cropp, Ashton T. , Chin, Jason W. , Anderson, Christopher J. , Schultz, Peter G.
IPC分类号： C07C269/06 , C07C311/41 , C07C227/22 , C07C229/36 , C07K1/107 , C07K1/13 , C09B11/08 , C09B57/00 , C07K14/01 , C07K14/00 , C12P21/02 , C12N9/00 , C12N15/67 , C12P17/04 , C07K16/18 , G01N33/532
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
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