公开(公告)号：EP4491628A1

公开(公告)日：2025-01-15

申请号：EP23766985.8

申请日：2023-03-10

Applicant: Nihon Medi-Physics Co., Ltd. ,  Kagoshima University

Inventor： TONOYA, Gota ,  SATO, Mikiko ,  TAKEDA, Takuya ,  UENO, Atsushi ,  ITO, Yuji ,  NAKAYAMA, Hiroshi

IPC: C07K7/08 ,  C07K1/13 ,  C07K1/16 ,  C07K16/00

Abstract: A method for producing an Fc-containing molecule modifying reagent, including reacting a protein or peptide with a crosslinking agent in the presence of a base having a stronger basicity than pyridine to bond an amino group in the protein or peptide with the crosslinking agent.

公开(公告)号：EP4486397A1

公开(公告)日：2025-01-08

申请号：EP23762640.3

申请日：2023-03-02

Applicant: Point Biopharma, Inc.

Inventor： MCCANN, Joe ,  DORNAN, Mark

IPC: A61K51/08 ,  A61K47/22 ,  A61P35/00 ,  C07B59/00 ,  C07K1/13 ,  C07K7/06

公开(公告)号：EP4130022B1

公开(公告)日：2024-11-13

申请号：EP21788695.1

申请日：2021-04-09

Inventor： GAO, Xiang ,  WANG, Xiaoyu ,  HUANG, Chengting ,  ZHAO, Yufen

IPC: C07K5/062 ,  C07K1/06 ,  C07K1/02 ,  C07K1/13 ,  G01N33/68 ,  G01N30/06 ,  C07B59/00 ,  G01N30/34 ,  G01N30/88 ,  G01N30/74

公开(公告)号：EP4452997A1

公开(公告)日：2024-10-30

申请号：EP22912469.8

申请日：2022-12-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： SUSSMAN, Michael ,  MINKOFF, Benjamin ,  WOLFER, Jamison ,  BURCH, Heather

IPC: C07K1/107 ,  C07K1/13 ,  C07D249/04 ,  C01B21/08 ,  C07C2/38 ,  C07D499/40 ,  A61K47/68

公开(公告)号：EP4413002A1

公开(公告)日：2024-08-14

申请号：EP22879191.9

申请日：2022-10-04

Applicant: The Trustees of Princeton University

Inventor： GERI, Jacob, B. ,  BUKSH, Benito, F. ,  MACMILLAN, David, W., C.

IPC: C07D487/22 ,  B01J35/00 ,  C07K1/13 ,  A61K41/00

CPC classification number: C07K1/13 ,  C07D417/14 ,  C07D235/26 ,  C07D405/12 ,  C07D403/12 ,  C07D241/44 ,  G01N33/542 ,  G01N33/533 ,  G01N33/6845 ,  G01N2500/1020130101 ,  G01N2500/2020130101 ,  B01J35/39 ,  B01J2531/02520130101 ,  B01J2531/4220130101 ,  B01J31/006 ,  B01J31/1835 ,  B01J2231/6420130101 ,  B01J2540/1220130101 ,  B01J2540/6620130101 ,  B01J2540/6820130101

公开(公告)号：EP2964658B1

公开(公告)日：2024-08-07

申请号：EP14759809.8

申请日：2014-03-07

IPC: C07F5/02 ,  A61K51/04 ,  A61K51/08 ,  C07B59/00 ,  C07K1/13

CPC classification number: C07B59/00 ,  C07K1/13 ,  C07F5/02 ,  A61K51/0421 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/082 ,  A61K51/04

公开(公告)号：EP4348267A2

公开(公告)日：2024-04-10

申请号：EP22812134.9

申请日：2022-05-26

Applicant: Board of Regents, The University of Texas System ,  Erisyon, Inc.

Inventor： MARCOTTE, Edward ,  ANSLYN, Eric ,  SWAMINATHAN, Jagannath ,  HOWARD, Cecil, J. II ,  BARDO, Angela, M. ,  SIMPSON, Zachary, Booth

IPC: G01N33/68 ,  C07K1/13 ,  G01N33/58

公开(公告)号：EP4227315A1

公开(公告)日：2023-08-16

申请号：EP22762458.2

申请日：2022-02-27

Applicant: Yantai Lannacheng Biotechnology Co., Ltd.

Inventor： CHEN, Xiaoyuan ,  XU, Pengfei

IPC: C07K5/062 ,  C07K7/02 ,  C07K1/06 ,  C07K1/107 ,  C07K1/13 ,  A61K51/08 ,  A61K45/06 ,  A61P35/00

Abstract: The present disclosure provides a compound targeting prostate specific membrane antigen (PSMA), wherein the compound has the following structure shown in Formula (I); R 1 is a compound structure targeting prostate specific membrane antigen; L 1 is -(X) n -(CH 2 ) m -(Y) q -, X and Y are independently selected from lysine, glutamic acid or a derivative structure containing lysine and glutamic acid, n is an integer from 0 to 12, m is an integer from 0 to 60, q is an integer from 0 to 12, and each CH 2 may be individually substituted with -O-, -NH(CO)-, or -(CO)-NH-; L 2 is -(CH 2 ) p -, p is an integer from 0 to 30, and each CH 2 may be individually substituted with -O-, -NH(CO)-, or -(CO)-NH-; and R 2 is a nuclide chelating group. The present disclosure also provides a radiolabeled complex based on the structure of the compound. The compound and the radiolabeled complex have appropriate blood circulation time, high uptake in tumors and long retention time, and are suitable for nuclide therapy and imaging of tumors with high expression of PSMA.

公开(公告)号：EP4180438A1

公开(公告)日：2023-05-17

申请号：EP22215508.7

申请日：2014-03-14

Applicant: Cancer Targeted Technology LLC ,  Washington State University

Inventor： BERKMAN, Clifford ,  STEKHOVA, Svetlana, A.

IPC: C07F9/22 ,  A61K51/08 ,  C07K1/13 ,  C07F9/58 ,  C07F9/24 ,  A61K51/04

Abstract: Compounds of Markush formula (I) described in the claims are useful in diagnostic methods for detecting and/or identifying cells presenting PSMA. Disclosed are also methods for preparing the compounds. Representative compounds according to the application are:

公开(公告)号：EP3986465A1

公开(公告)日：2022-04-27

申请号：EP20732640.6

申请日：2020-06-18

Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V. ,  Universität Heidelberg

Inventor： BENK, Amelie S. ,  SCHENK, Franziska ,  WEGNER, Seraphine ,  COMBA, Peter ,  SPATZ, Joachim P.

IPC: A61K47/30 ,  A61K47/64 ,  C07F15/06 ,  C07K1/13