发明公开
- 专利标题: BENZOFURAN DERIVATIVES
- 专利标题(中): 苯并呋喃
-
申请号: EP10710111.5申请日: 2010-03-09
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公开(公告)号: EP2406243A1公开(公告)日: 2012-01-18
- 发明人: TSUKAMOTO, Tetsuya , WAKABAYASHI, Takeshi , OHRA, Taiichi
- 申请人: Takeda Pharmaceutical Company Limited
- 申请人地址: 1-1 Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: 1-1 Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构: Held, Stephan
- 优先权: JP2009056719 20090310
- 国际公布: WO2010104194 20100916
- 主分类号: C07D307/79
- IPC分类号: C07D307/79 ; C07D307/80 ; C07D307/81 ; C07D405/04 ; C07D405/12 ; C07D405/14 ; C07D407/04 ; C07D407/12 ; C07D413/04 ; C07D413/12 ; C07D417/12 ; C07D493/10 ; A61K31/496 ; A61K31/5377 ; A61K31/551
摘要:
The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted bomopiperazine ring; R
1 and R
2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R
3 and R
4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R
3 to R
7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycIoaJkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein R
2 and R
3 do not exist when carbon atoms respectively adjacent to R
2 : and R
3 form a double bond, and there is no case where all of R
1 to R
7 are hydrogen atoms, and R
1 and R
2 ; may form a ring together with an adjacent carbon atom; or a salt thereof.
1 and R
2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R
3 and R
4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R
3 to R
7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycIoaJkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein R
2 and R
3 do not exist when carbon atoms respectively adjacent to R
2 : and R
3 form a double bond, and there is no case where all of R
1 to R
7 are hydrogen atoms, and R
1 and R
2 ; may form a ring together with an adjacent carbon atom; or a salt thereof.
公开/授权文献
- EP2406243B1 BENZOFURAN DERIVATIVES 公开/授权日:2014-05-07
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