-
公开(公告)号：EP2625170A1
公开(公告)日：2013-08-14
申请号：EP11778987.5
申请日：2011-10-05
发明人： ISHICHI, Yuji , YAMADA, Masami , KAMEI, Taku , FUJIMORI, Ikuo , NAKADA, Yoshihisa , YUKAWA, Tomoya , SAKAUCHI, Nobuki , OHBA, Yusuke , TSUKAMOTO, Tetsuya
IPC分类号： C07D267/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14
CPC分类号： C07D267/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/08
摘要： Provided is a compound having a monoamine reuptake inhibitory activity, which is represented by the formula (I) wherein ring A is an optionally substituted 6-membered aromatic ring, ring B is the substituents on ring A are optionally bonded to form, together with ring A, an optionally substituted 9- or 10-membered aromatic fused ring, and other symbols are as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供具有单胺再摄取抑制活性的化合物，其由式（I）表示，其中环A为任选取代的6-元芳环，环B为环A上的取代基任选键合以与环 A，任选取代的9-或10-元芳族稠合环，以及其它符号如说明书中所定义，或其盐。
-
公开(公告)号：EP2406243A1
公开(公告)日：2012-01-18
申请号：EP10710111.5
申请日：2010-03-09
IPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D493/10 , A61K31/496 , A61K31/5377 , A61K31/551
CPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D493/10
摘要： The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted bomopiperazine ring; R
1 and R
2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R
3 and R
4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R
3 to R
7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycIoaJkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein R
2 and R
3 do not exist when carbon atoms respectively adjacent to R
2 : and R
3 form a double bond, and there is no case where all of R
1 to R
7 are hydrogen atoms, and R
1 and R
2 ; may form a ring together with an adjacent carbon atom; or a salt thereof.-
公开(公告)号：EP3124487A1
公开(公告)日：2017-02-01
申请号：EP15768768.2
申请日：2015-03-23
发明人： TSUKAMOTO, Tetsuya , NAKADA, Yoshihisa , MOCHIZUKI, Michiyo , TAKAI, Takafumi , YUKAWA, Tomoya , SHIOKAWA, Zenyu , KATOH, Taisuke , SETOH, Masaki , SATO, Ayumu , YUKAWA, Takafumi
IPC分类号： C07D471/04 , A61K31/4439 , A61K31/4709 , A61K31/502 , A61K31/52 , A61P1/04 , A61P7/06 , A61P11/06 , A61P17/00 , A61P17/06 , A61P21/04 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07B59/002 , C07B2200/05 , C07D487/04 , C07D519/00
摘要： Provided is a compound having a superior PKC inhibitory action, and useful as a prophylactic or therapeutic agent for immune diseases, inflammatory diseases and the like, or a salt thereof. A compound represented by the formula (I):
wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a superior PKC inhibitory action, and is useful as a prophylactic or therapeutic agent for immune diseases, inflammatory diseases and the like.摘要翻译： 本发明提供具有优异的PKC抑制作用并且可用作免疫疾病，炎症性疾病等的预防或治疗剂或其盐的化合物。 由式（I）表示的化合物或其盐：其中每个符号如描述中所述，或其盐具有优良的PKC抑制作用，并且可用作免疫疾病，炎性疾病等的预防或治疗剂。
-
公开(公告)号：EP1637527A1
公开(公告)日：2006-03-22
申请号：EP04746824.4
申请日：2004-06-25
发明人： OHKAWA, Shigenori , TSUKAMOTO, Tetsuya , KIYOTA, Yoshihiro , GOTO, Mika , YAMAMOTO, Shouzou , SHIMOJOU, Masato , SETOU, Masaki
IPC分类号： C07D307/79 , C07D307/80 , C07D405/10 , C07D333/54 , C07D405/06 , C07D407/04 , C07D405/04 , C07D417/04 , C07D409/04 , A61K31/343
CPC分类号： C07D307/83 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/426 , A61K31/443 , A61K31/453 , A61K31/506 , C07D307/79 , C07D307/86 , C07D333/54 , C07D405/04
摘要： A cannabinoid receptor modulator containing a compound represented by Formula (I 0 )
wherein, X is an oxygen atom, etc., R° is an optionally substituted acylamino group, ring A 0 is a benzene ring which may further have a substituent in addition to R°, and ring B is an optionally substituted 5-membered heterocycle, or a salt thereof or a prodrug thereof.摘要翻译： 含有由式（I 0）表示的化合物的大麻素受体调节剂，其中X为氧原子等，R 0为任选取代的酰基氨基，环A 0为可以进一步具有取代基的苯环， R'和环B是任选取代的5元杂环，或其盐或其前药。
-
公开(公告)号：EP2832734A1
公开(公告)日：2015-02-04
申请号：EP13769902.1
申请日：2013-03-27
发明人： TSUKAMOTO, Tetsuya , OHBA, Yusuke , YUKAWA, Takafumi , NAGAMIYA, Hiroyuki , KAMEI, Taku , TOKUNAGA, Norihito , SAITOH, Morihisa , OKABE, Atsutoshi
IPC分类号： C07D401/04 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P37/02 , A61P43/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
CPC分类号： C07D403/04 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/107
摘要： The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.
The present invention relates to a compound represented by the formula
wherein each symbol is as defined in the specification, or a salt thereof.-
6.发明公开FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT 审中-公开简明三唑用于治疗或预防轻度认知障碍
公开(公告)号：EP2611805A1
公开(公告)日：2013-07-10
申请号：EP11791058.8
申请日：2011-09-01
发明人： KOIKE, Tatsuki , NAKAMURA, Minoru , TOMATA, Yoshihide , TAKAI, Takafumi , HOASHI, Yasutaka , KAJITA, Yuichi , TSUKAMOTO, Tetsuya , KAMATA, Makoto
IPC分类号： C07D471/04 , A61K31/4412 , A61K31/437 , A61P25/28
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
-
公开(公告)号：EP2406243B1
公开(公告)日：2014-05-07
申请号：EP10710111.5
申请日：2010-03-09
IPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D493/10 , A61K31/496 , A61K31/5377 , A61K31/551
CPC分类号： C07D307/79 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D493/10
-
公开(公告)号：EP1637527B1
公开(公告)日：2013-04-17
申请号：EP04746824.4
申请日：2004-06-25
发明人： OHKAWA, Shigenori , TSUKAMOTO, Tetsuya , KIYOTA, Yoshihiro , GOTO, Mika , YAMAMOTO, Shouzou , SHIMOJOU, Masato , SETOU, Masaki
IPC分类号： C07D307/79 , A61P25/00 , C07D307/80 , C07D405/10 , C07D333/54 , C07D405/06 , C07D407/04 , C07D405/04 , C07D417/04 , C07D409/04 , A61K31/343
CPC分类号： C07D307/83 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/426 , A61K31/443 , A61K31/453 , A61K31/506 , C07D307/79 , C07D307/86 , C07D333/54 , C07D405/04
-
9.发明授权BENZO-FUSED 5-MEMBERED HETROCYCLE COMPOUNDS,PROCESS FOR PREPARATION OF THE SAME, AND USE THEREOF 有权苯并稠合5元杂环化合物，用于生产及其用途
公开(公告)号：EP1411052B1
公开(公告)日：2011-10-05
申请号：EP02741413.5
申请日：2002-07-04
IPC分类号： C07D307/82 , C07D405/04 , C07D405/14 , C07D407/14 , A61K31/4525 , A61K31/496 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00
CPC分类号： A61K31/4525 , A61K31/496 , C07D307/79 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/83 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/04 , C07D409/14
摘要： Compounds represented by the general formula (I) or salts or prodrugs thereof are excellent in neurodegeneration inhibiting activity and migration toward the brain, have low toxicity, and are useful as preventive and therapeutic agents for neurodegenerative diseases: (I) wherein R1 and R2 are each independently hydrogen, a hydrocarbon group, or a heterocyclic group, or R1 and R2 together with the carbon atom adjacent thereto may form a 3- to 8-membered homo- or hetero-cycle; R3 is a cyclic group, hydroxyl, optionally oxo-modified mercapto, or amino; R4 is hydrogen, a hydrocarbon group, hydroxyl, optionally oxo-modified mercapto, or amino, or R2 and R4 may be united to form a double bond; X is a free valency or a linear hydrocarbon group; W is oxygen or sulfur; B is a 5- to 8-membered nitrogenous heterocycle; C is a benzene ring; and the symbol ... represents a single or double bond.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.033 秒)
