公开(公告)号：EP2300013B2

公开(公告)日：2024-11-13

申请号：EP09751617.3

申请日：2009-05-21

发明人： WANG, Yihan ,  HUANG, Wei-Sheng ,  LIU, Shuangying ,  SHAKESPEARE, William, C. ,  THOMAS, R., Mathew ,  QI, Jiwei ,  LI, Feng ,  ZHU, Xiaotian ,  KOHLMANN, Anna ,  DALGARNO, David, C. ,  ROMERO, Jan, Antoinette, C. ,  ZOU, Dong

IPC分类号： A61K31/505 ,  A61K31/513

公开(公告)号：EP3661922B1

公开(公告)日：2024-10-23

申请号：EP18755681.6

申请日：2018-08-03

发明人： TRAVINS, Jeremy ,  MILLER, Thomas ,  PAPAIOANNOU, Nikolaos

IPC分类号： C07D401/04 ,  A61K31/4025 ,  A61K31/427 ,  C07D417/04 ,  C07D417/14 ,  A61P7/10

公开(公告)号：EP4218797B1

公开(公告)日：2024-09-11

申请号：EP23172759.5

申请日：2010-09-21

IPC分类号： A61K38/48 ,  A61K9/08 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18

CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  A61K9/19 ,  A61K38/4886 ,  C12Y304/24087 ,  A61P7/02 ,  A61P9/10 ,  Y02A50/30

公开(公告)号：EP4410965A1

公开(公告)日：2024-08-07

申请号：EP22873026.3

申请日：2022-09-26

申请人： Kyoto University ,  Takeda Pharmaceutical Company Limited

发明人： KANEKO, Shin ,  IRIGUCHI, Shoichi ,  KASSAI, Yoshiaki ,  SEKIYA, Keiko ,  MATSUDA, Atsushi ,  SATO, Takayuki

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  C12N5/0735 ,  C12N5/10 ,  C12N15/13

CPC分类号： A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  C07K16/00 ,  C12N5/06 ,  C12N5/10 ,  A61K39/46433 ,  A61K39/4621 ,  A61K39/4611

摘要： Disclosed is a method for producing regulatory T cells, the method comprising:
(1) differentiating cells that can differentiate into regulatory T cells, into which an expression construct is introduced, into regulatory T cells, the expression construct comprising:
(a) conserved non-coding sequence (CNS) 1, CNS2, and CNS3 of Foxp3 gene;
(b) a promoter; and
(c) a nucleic acid encoding FOXP3.

Also disclosed are regulatory T cells obtained by the method, and a pharmaceutical composition comprising the regulatory T cells.

公开(公告)号：EP3400940B1

公开(公告)日：2024-08-07

申请号：EP17735993.2

申请日：2017-01-05

IPC分类号： A61K31/423 ,  A61K31/428 ,  A61P25/00 ,  A61K31/4439

CPC分类号： A61K31/428 ,  A61K31/423 ,  A61P25/00 ,  A61K31/4439

公开(公告)号：EP4031547B1

公开(公告)日：2024-07-17

申请号：EP20785878.8

申请日：2020-09-17

IPC分类号： C07D471/04 ,  A61P9/00 ,  A61P29/00 ,  A61K31/437

CPC分类号： C07D471/04 ,  A61P29/00 ,  A61P9/00

公开(公告)号：EP4388124A1

公开(公告)日：2024-06-26

申请号：EP21789808.9

申请日：2021-08-20

申请人： Takeda Pharmaceutical Company Limited

发明人： WEBER, Alfred ,  GRITSCH, Herbert ,  SCHRENK, Gerald ,  BILLWEIN, Manfred ,  ENGELMAIER, Andrea ,  ZLABINGER, Christoph ,  DOCKAL, Michael

IPC分类号： C12Q1/56 ,  G01N33/86 ,  G01N33/58

CPC分类号： C12Q1/56 ,  G01N33/86 ,  G01N33/583 ,  G01N2333/75520130101

公开(公告)号：EP4338830A3

公开(公告)日：2024-06-12

申请号：EP23203872.9

申请日：2018-07-30

申请人： Takeda Pharmaceutical Company Limited

发明人： TOSO, Robert ,  SPANGGORD, Richard ,  TAN, Mei ,  TAIARIOL, Van ,  LIN, Yekaterina

IPC分类号： B01J19/00 ,  B01J20/32 ,  B29B9/16 ,  B01J19/18

CPC分类号： B01J4/004 ,  B01J19/18 ,  B01J19/0066 ,  B01F27/13 ,  B01F35/451 ,  B01F35/712

摘要： A resin washing apparatus comprising: a vessel comprising a cylinder divided into an upper portion and a lower portion by a screen stretched across the cylinder, the upper portion comprising an inlet and the lower portion comprising an outlet; and an agitator disposed within the upper portion, the agitator comprising a rotor and a rotating impeller comprising a hub, a first blade, and a second blade, the first and second blades extending in opposite directions perpendicularly from the hub, each blade having an axis transverse to the axis of the rotor upon which the hub is configured to rotate; wherein the screen comprises a mesh material with a pore size between about 5 µm and about 80 µm; and wherein the agitator is configured to impart a force to a fluid in the vessel, wherein the force is directed away from the screen.

公开(公告)号：EP4034257B1

公开(公告)日：2024-05-22

申请号：EP20807102.7

申请日：2020-09-25

IPC分类号： A61P43/00 ,  C07D213/61 ,  C07D213/65 ,  C07D213/68 ,  C07D221/04 ,  C07D239/34 ,  C07D333/38 ,  C07D401/12 ,  A61K31/495 ,  A61K31/444 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07D213/65 ,  C07D213/61 ,  C07D213/68 ,  C07D239/34 ,  C07D401/12 ,  C07D333/38 ,  C07D221/04 ,  A61P25/00 ,  A61P29/00

公开(公告)号：EP4299735A3

公开(公告)日：2024-04-24

申请号：EP23210110.5

申请日：2010-08-02

申请人： Takeda Pharmaceutical Company Limited

发明人： Hasslacher, Meinhard ,  Mitterer, Artur, Dr. ,  Fiedler, Christian ,  Mayer, Christa

IPC分类号： C12N9/64 ,  A61P7/00 ,  A61P9/00 ,  C12M1/00 ,  C12N11/14 ,  A61P7/02

CPC分类号： C12Y304/24087 ,  C12M47/12 ,  C12N11/14 ,  C12N9/6489 ,  A61P7/02 ,  A61P9/00

摘要： Provided herein are methods for purifying recombinant A Disintegrin-like and Metallopeptidase with Thrombospondin Type 1 Motif 13 (ADAMTS13) protein from a sample. The method comprises enriching for ADAMTS13 protein by chromatographically contacting the sample with hydroxyapatite under conditions that allow ADAMTS13 protein to appear in the eluate or supernatant from the hydroxylapatite. The methods may further comprise tandem chromatography with a mixed mode cation exchange/hydrophobic interaction resin that binds ADAMTS13 protein. Additional optional steps involve ultrafiltration/diafiltration, anion exchange chromatography, cation exchange chromatography, and viral inactivation. Also provided herein are methods for inactivating virus contaminants in protein samples, where the protein is immobilized on a support. Also provided herein are compositions of ADAMTS13 prepared according to said methods.