发明公开
EP2471910A2 PREPARATION METHOD OF LACTATE POLYMERS AND LACTATE COPOLYMERS USING POLYHYDROXYALKANOATE SYNTHASE MUTANTS
审中-公开
聚羟基乙酸酯合成酶突变体制备乳酸聚合物和乳酸盐共聚物的方法
- 专利标题： PREPARATION METHOD OF LACTATE POLYMERS AND LACTATE COPOLYMERS USING POLYHYDROXYALKANOATE SYNTHASE MUTANTS
- 专利标题（中）： 聚羟基乙酸酯合成酶突变体制备乳酸聚合物和乳酸盐共聚物的方法
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申请号： EP10794355.7申请日： 2010-06-30
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公开(公告)号： EP2471910A2公开(公告)日： 2012-07-04
- 发明人: YANG, Taek Ho , KANG, Hye Ok , LEE, Sang Yup , JUNG, Yu Kyung
- 申请人： LG Chem, Ltd. , Korea Advanced Institute of Science and Technology
- 申请人地址： 20, Yoido-dong Youngdungpo-gu Seoul 150-721 KR
- 专利权人： LG Chem, Ltd.,Korea Advanced Institute of Science and Technology
- 当前专利权人： LG Chem, Ltd.,Korea Advanced Institute of Science and Technology
- 当前专利权人地址： 20, Yoido-dong Youngdungpo-gu Seoul 150-721 KR
- 代理机构： Goddar, Heinz J.
- 优先权： KR20090059488 20090630
- 国际公布： WO2011002220 20110106
- 主分类号： C12N9/00
- IPC分类号： C12N9/00 ; C12N15/52 ; C12P7/56
摘要：
Mutants of various polyhydroxyalkanoate (PHA) synthases capable of synthesizing a lactate polymer (PLA) and a lactate copolymer (PLA copolymer), and a method of preparing a lactate polymer and a lactate copolymer using the same are provided. More specifically, a mutant of polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8, and a method of preparing lactate polymer and lactate copolymer using the mutant of synthase are provided. The polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8 can have an activity of synthesizing a lactate polymer and a lactate copolymer by an amino acid sequence mutation affecting an activity of synthesizing a lactate polymer, and can produce a lactate polymer and a copolymer that have different features, respectively, by using the mutants of the synthase.
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