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1.发明公开METHOD FOR PREPARING POLYLACTATE AND COPOLYMER THEREOF USING A MUTANT MICROORGANISM WITH ENHANCED POLYLACTATE, AND THE COPOLYMER PRODUCING CAPABILITY THEREOF 审中-公开用于生产聚乳酸及其共聚物通过改进聚乳酸与能力COPOLYMERERZEUGENDER突变的微生物手段
公开(公告)号：EP2314638A2
公开(公告)日：2011-04-27
申请号：EP09770374.8
申请日：2009-06-24
发明人： YANG, Taek Ho , PARK, Si Jae , KIM, Tae Wan , LEE, Sang Yup , JUNG, Yu Kyung
IPC分类号： C08G63/91
摘要： Provided is a method of preparing polylactate (PLA) or a copolymer thereof using a mutant microorganism in which a gene participating in a coenzyme A (CoA) donor- and lactate-producing pathway is genetically manipulated to increase the productivity of a CoA donor and lactate. Amounts of the CoA donor and the lactate are simultaneously increased in a microbial metabolic pathway to enable effective biosynthesis of PLA and a hydroxyalkanoate-lactate copolymer having a high content of lactate, which is industrially useful.
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2.发明授权MUTANTS HAVING CAPABILITY TO PRODUCE 1,4-BUTANEDIOL AND METHOD FOR PREPARING 1,4-BUTANEDIOL USING THE SAME 有权突变体的能力生产1,4-丁二醇和用于生产1,4-丁二醇THEREOF USING
公开(公告)号：EP2201115B1
公开(公告)日：2012-10-24
申请号：EP08793214.1
申请日：2008-08-13
发明人： PARK, Si Jae , LEE, Sang Hyun , LEE, Sang Yup , LEE, Eun Jeong
IPC分类号： C12N15/10
CPC分类号： C12N15/77 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12P7/18 , C12Y101/01061 , C12Y102/01024 , C12Y103/99002
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3.发明公开MUTANTS HAVING CAPABILITY TO PRODUCE 1,4-BUTANEDIOL AND METHOD FOR PREPARING 1,4-BUTANEDIOL USING THE SAME 有权突变体的能力生产1,4-丁二醇和用于生产1,4-丁二醇THEREOF USING
公开(公告)号：EP2201115A2
公开(公告)日：2010-06-30
申请号：EP08793214.1
申请日：2008-08-13
发明人： PARK, Si Jae , LEE, Sang Hyun , LEE, Sang Yup , LEE, Eun Jeong
IPC分类号： C12N15/10
CPC分类号： C12N15/77 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12P7/18 , C12Y101/01061 , C12Y102/01024 , C12Y103/99002
摘要： A mutant capable of producing 1,4-butanediol and a method of preparing 1,4- butanediol using the same are provided. The mutant microorganism is prepared by introducing and amplifying genes encoding enzymes converting succinate into 4- hydroxybutyrate and 4-hydroxybutyrate into 1,4-butanediol in a microorganism capable of producing succinate. The method includes culturing the mutant in a medium containing carbohydrate and obtaining 1,4-butanediol from the culture. Thus, 1,4-butanediol, which is essential in chemical industry, can be prepared in a biological process.
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4.发明授权MUTANTS HAVING CAPABILITY TO PRODUCE 1,4-BUTANEDIOL AND METHOD FOR PREPARING 1,4-BUTANEDIOL USING THE SAME 有权突变体的能力生产1,4-丁二醇和用于生产1,4-丁二醇THEREOF USING
公开(公告)号：EP2201115B2
公开(公告)日：2016-07-20
申请号：EP08793214.1
申请日：2008-08-13
发明人： PARK, Si Jae , LEE, Sang Hyun , LEE, Sang Yup , LEE, Eun Jeong
IPC分类号： C12N15/10
CPC分类号： C12N15/77 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12P7/18 , C12Y101/01061 , C12Y102/01024 , C12Y103/99002
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5.发明公开PREPARATION METHOD OF LACTATE POLYMERS AND LACTATE COPOLYMERS USING POLYHYDROXYALKANOATE SYNTHASE MUTANTS 审中-公开聚羟基乙酸酯合成酶突变体制备乳酸聚合物和乳酸盐共聚物的方法
公开(公告)号：EP2471910A2
公开(公告)日：2012-07-04
申请号：EP10794355.7
申请日：2010-06-30
发明人： YANG, Taek Ho , KANG, Hye Ok , LEE, Sang Yup , JUNG, Yu Kyung
CPC分类号： C12P7/625 , C12N9/13 , C12P7/56 , C12Y208/03001
摘要： Mutants of various polyhydroxyalkanoate (PHA) synthases capable of synthesizing a lactate polymer (PLA) and a lactate copolymer (PLA copolymer), and a method of preparing a lactate polymer and a lactate copolymer using the same are provided. More specifically, a mutant of polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8, and a method of preparing lactate polymer and lactate copolymer using the mutant of synthase are provided. The polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2, 4, 6, or 8 can have an activity of synthesizing a lactate polymer and a lactate copolymer by an amino acid sequence mutation affecting an activity of synthesizing a lactate polymer, and can produce a lactate polymer and a copolymer that have different features, respectively, by using the mutants of the synthase.
摘要翻译： 提供了能够合成乳酸酯聚合物（PLA）和乳酸酯共聚物（PLA共聚物）的各种聚羟基链烷酸酯（PHA）合酶的突变体，以及使用该突变体制备乳酸酯聚合物和乳酸酯共聚物的方法。 更具体而言，提供了SEQ ID NO：2,4,6或8中所示的聚羟基链烷酸酯合酶的突变体，以及使用该合酶突变体来制备乳酸盐聚合物和乳酸盐共聚物的方法。 在SEQ ID NO：2,4,6或8中列出的聚羟基链烷酸酯合酶可以具有通过影响合成乳酸聚合物活性的氨基酸序列突变合成乳酸酯聚合物和乳酸酯共聚物的活性，并且可以产生 乳酸聚合物和具有不同特征的共聚物，分别通过使用合酶的突变体。
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公开(公告)号：EP4001406A2
公开(公告)日：2022-05-25
申请号：EP21205995.0
申请日：2021-11-02
发明人： LEE, Sang Yup , YANG, Dongsoo , PARK, Seon Young
摘要： Disclosed are a recombinant microorganism for producing a hydrophobic material, which is subjected to cell-membrane engineering in order to be imparted with at least one characteristic among an increase in a cell-membrane area, an increase in formation and secretion of an outer membrane vesicle, and an increase in formation of an inner membrane vesicle, and a cell-membrane engineering method for preparation thereof, whereby an insoluble hydrophobic material can be produced with high efficiency, the recombinant microorganism for high-efficiency production of carotenoids or violacein analogues is useful for producing natural pigments, antioxidants, antibiotics, cosmetic additives, anticancer agents, food additives, or nutritional supplements, and the natural pigment production technology developed herein achieves a great increase in production ability. Therefore, the present invention is effective at preparing a recombinant strain for efficient production of a variety of industrially and medically useful metabolites and at establishing an efficient preparation method.
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公开(公告)号：EP3884951A1
公开(公告)日：2021-09-29
申请号：EP19886811.9
申请日：2019-11-21
发明人： LEE, Sang Yup , YOO, Won Min , KIM, Sooncheol , CHUNG, Hannah , NA, Deok Hyun
摘要： The present invention relates to a composition for treating hair loss or promoting hair growth which contains a silk protein, and plasma or serum components. According to the present invention, due to the synergistic effect of a silk protein and plasma or serum components, the effect of promoting hair growth and the effect of treating hair loss can be expected to be more efficient.
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8.发明公开
公开(公告)号：EP3741860A1
公开(公告)日：2020-11-25
申请号：EP19740842.0
申请日：2019-01-15
发明人： LEE, Sang Yup , CHO, Jae Sung , KIM, Je Woong , KO, Yoo Sung , PRABOWO, Cindy Pricilia Surya , HAN, Taehee , KIM, Euiduk , CHOI, Jae Won , CHO, Changhee , LEE, Jun Kyu
摘要： The present disclosure relates to a mutant microorganism in which a glycerol catabolic pathway and a 1,3-PDO biosynthetic pathway are introduced into a microorganism incapable of using glycerol as a carbon source, and a method of producing 1,3-PDO using the same. According to the present disclosure, it is possible to produce 1,3-PDO while growing a mutant microorganism having 1,3-PDO production ability by using the inexpensive raw material glycerol as a single carbon source. Thus, the present disclosure is useful for the economical production of 1,3-PDO.
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公开(公告)号：EP3660157A9
公开(公告)日：2020-07-29
申请号：EP19762287.1
申请日：2019-05-02
发明人： LEE, Sang Yup , KIM, Kyung-Jin , AHN, Jung Ho , SEO, Hogyun , LEE, Jong An
摘要： Disclosed are a mutant microorganism for producing succinic acid exhibiting improved activity of conversion of oxaloacetate to malate through the introduction of genes encoding a malate dehydrogenase, wherein an amino acid residue that interacts with a pyrophosphate moiety of NADH through an amide functional group of a main chain of malate dehydrogenase is glutamine (Gln), and a method of producing succinic acid using the same. The mutant microorganism producing succinic acid according to the present invention is capable of producing a high concentration of succinic acid at the highest productivity compared to other mutant microorganisms reported to date when the microorganism is cultured in a limited medium. In addition, the mutant microorganism is capable of producing succinic acid at higher productivity and product concentration through further advanced fermentation technology.
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10.发明授权
公开(公告)号：EP2281880B1
公开(公告)日：2016-07-06
申请号：EP09729276.7
申请日：2009-03-05
发明人： LEE, Sang Yup , QIAN, Zhi Gang , XIA, Xiaoxia , JEON, Yong Jae
CPC分类号： C12P13/001
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