发明公开
- 专利标题： GENETICALLY ENCODED CALCIUM INDICATORS AND METHODS OF USE
- 专利标题（中）： 遗传编码的钙指标及其使用方法
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申请号： EP10829090.9申请日： 2010-11-04
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公开(公告)号： EP2496697A2公开(公告)日： 2012-09-12
- 发明人: LOOGER, Loren, Lee , TIAN, Lin
- 申请人： Howard Hughes Medical Institute
- 申请人地址： 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789 US
- 专利权人： Howard Hughes Medical Institute
- 当前专利权人： Howard Hughes Medical Institute
- 当前专利权人地址： 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789 US
- 代理机构： Bassil, Nicholas Charles
- 优先权： US258738P 20091106
- 国际公布： WO2011056975 20110512
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12Q1/68 ; C07K14/705 ; G01N33/68
摘要：
Provided herein are nucleic acid sequences and polypeptides encoding a genetically encoded calcium indicator (GECI). Also provided are vectors and cells comprising the nucleic acid sequences and/or polypeptides. Kits comprising the nucleic acid sequences, polypeptides, vectors, cells and combinations thereof are also provided. Also provided herein are methods of screening for G-protein coupled receptor (GPCR) agonists and antagonists and methods of monitoring neural activity using the GECIs.
公开/授权文献
- EP2496697B1 GENETICALLY ENCODED CALCIUM INDICATORS AND METHODS OF USE 公开/授权日：2017-04-12
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