发明公开
EP2507254A1 METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES
审中-公开
方法和组合物的蛋白质，肽和其他分子改进的F-18标记
- 专利标题： METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES
- 专利标题（中）： 方法和组合物的蛋白质，肽和其他分子改进的F-18标记
-
申请号： EP10835120.6申请日： 2010-12-02
-
公开(公告)号： EP2507254A1公开(公告)日： 2012-10-10
- 发明人: MCBRIDE, William, J. , D'SOUZA, Christopher, A. , GOLDENBERG, David, M.
- 申请人： Immunomedics, Inc.
- 申请人地址： 300 American Road Morris Plains, NJ 07950 US
- 专利权人： Immunomedics, Inc.
- 当前专利权人： Immunomedics, Inc.
- 当前专利权人地址： 300 American Road Morris Plains, NJ 07950 US
- 代理机构： Bohmann, Armin K.
- 优先权： US266773P 20091204; US302280P 20100208; US316125P 20100322; US347486P 20100524; US381720P 20100910; US388268P 20100930
- 国际公布： WO2011068965 20110609
- 主分类号： C07K1/13
- IPC分类号： C07K1/13 ; A61K51/00
摘要：
The present application discloses compositions and methods of synthesis and use of 68Ga, 18F or 19F labeled molecules of use in PET or MRI imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a chelating moiety, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 68Ga, 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. In more preferred embodiments, a chelating moiety or targetable construct may be conjugated to a targeting molecule, such as an antibody or antibody fragment.
信息查询
