公开(公告)号：EP1519958B1

公开(公告)日：2014-10-15

申请号：EP03740743.4

申请日：2003-06-16

申请人： Immunomedics, Inc.

发明人： GOLDENBERG, David, M. ,  HANSEN, Hans ,  QU, Zhengxing

IPC分类号： C07K16/18 ,  A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  C07K16/28 ,  C07K14/47

CPC分类号： A61K49/0008 ,  A61K47/68 ,  A61K51/1057 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/2896 ,  C07K2317/24

公开(公告)号：EP1546204B1

公开(公告)日：2013-09-18

申请号：EP03751001.3

申请日：2003-09-30

申请人： Immunomedics, Inc.

发明人： GOLDENBERG, David, M. ,  HANSEN, Hans ,  LEUNG, Shui-on

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K47/48 ,  A61K51/10 ,  A61K31/203 ,  A61K33/36 ,  A61K38/00 ,  A61K45/00 ,  A61K35/02 ,  G01N33/574 ,  G01N33/577 ,  C12N15/13 ,  C12N15/85 ,  C12N5/10

CPC分类号： G01N33/57426 ,  A61K39/395 ,  A61K51/10 ,  A61K51/1027 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/567 ,  C07K2319/00 ,  G01N2500/00 ,  A61K2300/00

公开(公告)号：EP1372718B1

公开(公告)日：2012-10-31

申请号：EP02725464.8

申请日：2002-04-03

申请人： Immunomedics, Inc.

发明人： HANSEN, Hans, J. ,  GRIFFITHS, Gary, L. ,  LEUNG, Shui-on ,  MCBRIDE, William, J. ,  QU, Zhengxing ,  GOLDENBERG, David, M.

IPC分类号： C07K16/30 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18

CPC分类号： C07K16/468 ,  A61K47/6863 ,  A61K47/6899 ,  A61K51/1048 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00

公开(公告)号：EP2507254A1

公开(公告)日：2012-10-10

申请号：EP10835120.6

申请日：2010-12-02

申请人： Immunomedics, Inc.

发明人： MCBRIDE, William, J. ,  D'SOUZA, Christopher, A. ,  GOLDENBERG, David, M.

IPC分类号： C07K1/13 ,  A61K51/00

CPC分类号： C07K19/00 ,  A61K47/6897 ,  A61K51/0406 ,  A61K51/0491 ,  A61K51/08 ,  A61K51/082 ,  A61K51/083 ,  A61K51/088 ,  A61K51/109 ,  B82Y5/00

摘要： The present application discloses compositions and methods of synthesis and use of 68Ga, 18F or 19F labeled molecules of use in PET or MRI imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a chelating moiety, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 68Ga, 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. In more preferred embodiments, a chelating moiety or targetable construct may be conjugated to a targeting molecule, such as an antibody or antibody fragment.

公开(公告)号：EP2396036A1

公开(公告)日：2011-12-21

申请号：EP09840166.4

申请日：2009-12-02

申请人： Immunomedics, Inc.

发明人： GOVINDAN, Serengulam, V. ,  MOON, Sung-Ju ,  GOLDENBERG, David, M.

IPC分类号： A61K39/44 ,  C12P21/08

CPC分类号： A61K47/6803 ,  A61K31/4745 ,  A61K45/06 ,  A61K47/6841 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6853 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6861 ,  A61K47/6889 ,  A61K2039/505 ,  A61N5/10 ,  C07D491/22 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2833 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/30 ,  C07K16/303 ,  C07K16/3046 ,  C07K16/3076 ,  C07K16/3092 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/94 ,  Y02A50/394 ,  Y02A50/401 ,  Y02A50/403 ,  Y02A50/412 ,  Y02A50/473 ,  Y02A50/478

摘要： The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.

摘要翻译： 本发明涉及具有改善靶向包含靶向部分（例如抗体或抗体片段），接头和治疗部分的各种病变细胞的能力改善的治疗性缀合物，并且还涉及制备和使用缀合物的方法。

公开(公告)号：EP1507562B1

公开(公告)日：2010-03-24

申请号：EP03730342.7

申请日：2003-05-28

申请人： Immunomedics, Inc.

发明人： GRIFFITHS, Gary, L. ,  GOLDENBERG, David, M.

IPC分类号： A61K51/10 ,  A61P35/00

CPC分类号： A61K51/109

摘要： A method for treating a brain tumor by administering to a patient (i) a multispecific antibody comprising at least one targeting arm that binds to a brain cancer antigen and at least one capture arm that binds to a radionuclide carrier; (ii) a therapeutic radionuclide carrier to which is bound a therapeutic radionuclide, wherein the multispecific antibody, radionuclide carrier and therapeutic radionuclide are administered in a substantially equimolar ratio.

摘要翻译： 一种通过给予患者（i）包含与脑癌抗原结合的至少一种靶向臂的多特异性抗体和与放射性核素载体结合的至少一种捕获臂来治疗脑肿瘤的方法。 （ii）与治疗性放射性核素结合的治疗性放射性核素载体，其中所述多特异性抗体，放射性核素载体和治疗性放射性核素以基本上等摩尔比施用。

公开(公告)号：EP1194167B1

公开(公告)日：2009-08-19

申请号：EP00941278.4

申请日：2000-06-09

申请人： Immunomedics, Inc.

发明人： GOLDENBERG, David, M. ,  HANSEN, Hans, J.

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K19/00 ,  A61P37/06 ,  C07K14/55

CPC分类号： C07K16/2887 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6813 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2317/24 ,  Y10S514/885 ,  Y10S514/903

摘要： Antibodies that bind with a B-cell antigen provide an effective means to treat autoimmune disorders. Antibodies and fragments, which may be conjugated or naked, are used alone or in multimodal therapies. The antibodies may be bispecific antibodies which may be produced recombinantly as fusion proteins, or as hybrid, polyspecific antibodies.

公开(公告)号：EP1509255B1

公开(公告)日：2008-04-16

申请号：EP03738247.0

申请日：2003-06-02

申请人： Immunomedics, Inc.

发明人： GRIFFITHS, Gary, L. ,  GOLDENBERG, David, M.

IPC分类号： A61K51/10 ,  A61K47/48

CPC分类号： B82Y5/00 ,  A61K9/0034 ,  A61K47/665 ,  A61K47/6897 ,  A61K51/1084 ,  A61K51/109

摘要： A method for treating bladder cancer by administering via the urethra a multispecific antibody comprising at least one targeting arm that binds a bladder cancer antigen and at least one capture arm that binds a carrier conjugated to one or more therapeutic agents, allowing said multispecific antibody to localize at the site of said bladder cancer, allowing any free multispecific antibody to substantially clear from the patient; and (b) administering a therapeutically effective amount of the carrier conjugated to one or more therapeutic agents.

公开(公告)号：EP1572131A2

公开(公告)日：2005-09-14

申请号：EP03774636.9

申请日：2003-10-08

申请人： Immunomedics, Inc.

发明人： GOLDENBERG, David, M. ,  HANSEN, Hans, J.

IPC分类号： A61K7/00

CPC分类号： A61K39/39558 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/513 ,  A61K31/519 ,  A61K31/555 ,  A61K31/655 ,  A61K31/675 ,  A61K31/704 ,  A61K38/164 ,  A61K38/168 ,  A61K38/1816 ,  A61K38/191 ,  A61K38/193 ,  A61K38/196 ,  A61K38/20 ,  A61K38/217 ,  A61K51/1045 ,  A61K51/1048 ,  A61K51/1096 ,  A61K2039/505 ,  C07K16/3007 ,  C07K2317/24 ,  A61K2300/00

摘要： The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this composition.

公开(公告)号：EP1546203A2

公开(公告)日：2005-06-29

申请号：EP03766456.2

申请日：2003-08-01

申请人： Immunomedics, Inc.

发明人： HANSEN, Hans ,  QU, Zhengxing ,  GOLDENBERG, David, M.

IPC分类号： C07K16/18 ,  C07K16/46 ,  A61K51/10 ,  A61K47/48 ,  A61K39/395 ,  G01N33/573 ,  G01N33/574 ,  C12N15/13 ,  C12N15/62 ,  C12N15/79 ,  C12N5/10 ,  A61P35/00 ,  C12Q1/68

CPC分类号： C07K16/30 ,  A61K41/0095 ,  A61K47/6843 ,  A61K49/0002 ,  A61K51/1018 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/3076 ,  C07K2317/24 ,  C07K2317/56 ,  G01N33/57484 ,  G01N33/689

摘要： The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.