发明授权
- 专利标题： REVERSE GENETICS OF NEGATIVE-STRAND RNA VIRUSES IN YEAST
- 专利标题（中）： 在酵母负链RNA病毒的反向遗传学
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申请号： EP09707059.3申请日： 2009-01-30
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公开(公告)号： EP2561081B1公开(公告)日： 2016-12-28
- 发明人: MILED, Chaouki , TANGY, Frédéric , JACOB, Yves
- 申请人： Institut Pasteur , Centre National de la Recherche Scientifique
- 申请人地址： 25-28 rue du Docteur Roux 75724 Paris Cédex 15 FR
- 专利权人： Institut Pasteur,Centre National de la Recherche Scientifique
- 当前专利权人： Institut Pasteur,Centre National de la Recherche Scientifique
- 当前专利权人地址： 25-28 rue du Docteur Roux 75724 Paris Cédex 15 FR
- 代理机构： Desaix, Anne
- 优先权： EP08290087 20080131
- 国际公布： WO2009095791 20090806
- 主分类号： A61K39/165
- IPC分类号： A61K39/165 ; C12N7/00 ; A61K39/00 ; A61K39/12 ; C07K14/005 ; C12N15/81
摘要：
The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA.
公开/授权文献
- EP2561081A1 REVERSE GENETICS OF NEGATIVE-STRAND RNA VIRUSES IN YEAST 公开/授权日：2013-02-27
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