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公开(公告)号：EP3071690B1
公开(公告)日：2020-07-29
申请号：EP14772304.3
申请日：2014-09-17
申请人： Institut Pasteur , Centre National de la Recherche Scientifique , Université Paris Diderot - Paris 7
发明人： SALA, Monica , JACOB, Daria , TANGY, Frédéric
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2.发明公开A DENGUE VIRUS CHIMERIC POLYEPITOPE COMPOSED OF FRAGMENTS OF NON-STRUCTURAL PROTEINS AND ITS USE IN AN IMMUNOGENIC COMPOSITION AGAINST DENGUE VIRUS INFECTION 审中-公开嵌合登革病毒FRAGMENTS多表位不是结构性蛋白及其连接，并以免疫原性组合物抗登革热病毒感染
公开(公告)号：EP3157555A1
公开(公告)日：2017-04-26
申请号：EP15735644.5
申请日：2015-06-22
发明人： TANGY, Frédéric , SHAKUNTABAI, Anavaj , SIMON-LORIERE, Etienne , ROTH, Claude , BUCHY, Philippe
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/54 , A61K2039/70 , C07K14/1825 , C07K2319/00 , C12N7/00 , C12N2760/18441 , C12N2760/18443 , C12N2770/24134 , Y02A50/386
摘要： The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in particular polynucleotides, vectors, cells and methods to produce vectors expressing said chimeric polyepitopes, in particular vectors consisting of recombinant measles virus (MV) particles. The present invention also relates to the use of the recombinant MV particles, in particular under the form of a composition or of a vaccine, for the prevention and/or treatment of a dengue virus infection.
摘要翻译： 本发明涉及的非结构蛋白及其在对抗登革热病毒感染一免疫原性组合物使用的片段组成的登革病毒的嵌合多表位。 本发明提供了装置，尤其是多核苷酸，载体，细胞和方法，以产生表达嵌合说抗原决定簇，尤其是向量，由重组麻疹病毒（MV）的颗粒载体。 因此，本发明涉及使用特别是重组MV颗粒的下组合物的形式或疫苗的，对于登革病毒感染的预防和/或治疗。
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公开(公告)号：EP2561081B1
公开(公告)日：2016-12-28
申请号：EP09707059.3
申请日：2009-01-30
发明人： MILED, Chaouki , TANGY, Frédéric , JACOB, Yves
IPC分类号： A61K39/165 , C12N7/00 , A61K39/00 , A61K39/12 , C07K14/005 , C12N15/81
CPC分类号： A61K39/165 , A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N15/81 , C12N2760/00051 , C12N2760/18434 , C12N2760/18451 , C12N2770/24134
摘要： The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA viruses in yeast, especially in budding yeast. Accordingly, the patent application relates to a recombinant yeast strain suitable for the rescue of infectious non-segmented negative-strand RNA virus particles or infectious virus-like particles. The invention also relates to the use of the recombinant yeast to prepare vaccine seed and to the use of the produced RNPs or RNPs-like to prepare vaccine formulations. It also concerns the use of the recombinant yeast for the screening of libraries of DNA.
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4.发明公开
公开(公告)号：EP3796932A1
公开(公告)日：2021-03-31
申请号：EP19779546.1
申请日：2019-05-23
发明人： TANGY, Frédéric , MURA, Marie , AMINO, Rogerio , CHITNIS, Chetan
IPC分类号： A61K39/015 , A61P33/06 , C07K14/445 , C12N15/62 , C12N15/86
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5.发明公开
公开(公告)号：EP3474892A1
公开(公告)日：2019-05-01
申请号：EP17752483.2
申请日：2017-06-23
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6.发明公开RECOMBINANT LENTIVIRAL VECTOR FOR EXPRESSION OF A FLAVIVIRIDAE PROTEIN AND APPLICATIONS THEREOF AS A VACCINE 有权为了表达黄病毒科病毒的蛋白质重组慢病毒载体，其使用作为疫苗
公开(公告)号：EP1751291A1
公开(公告)日：2007-02-14
申请号：EP05748053.5
申请日：2005-05-16
IPC分类号： C12N15/867 , C07K14/18
CPC分类号： C12N15/86 , A61K2039/53 , C07K14/005 , C12N2740/16043 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/394
摘要： Use of a recombinant lentiviral vector comprising a polynucleotide fragment encoding at least one protein of a virus of the family Flaviviridae or an immunogenic peptide of at least 8 amino acids of said protein, for preparing a pharmaceutical composition intended for the prevention and/or the treatment of a Flaviviridae infection in a sensitive species.
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公开(公告)号：EP3727411A2
公开(公告)日：2020-10-28
申请号：EP18857393.5
申请日：2018-12-20
发明人： MATEO, Mathieu , BAIZE, Sylvain , TANGY, Frédéric
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公开(公告)号：EP3412307A1
公开(公告)日：2018-12-12
申请号：EP17305676.3
申请日：2017-06-07
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/53 , C12N2710/14034 , C12N2710/14041 , G01N2333/12
摘要： The present invention relates to recombinant measles virus expressing Zika virus proteins and their applications, in particular in inducing preventive protection against Zika virus. The present invention is directed to recombinant measles virus (MV) expressing at least (i) the precursor of membrane (prM) protein of a Zika virus (ZIKV), and the envelope (E) protein of a ZIKV or a truncated version thereof, or (ii) the E protein of a ZIKV or a truncated version thereof, and concerns recombinant infectious particles of said MV-ZIKV able to replicate in a host after an administration, and also Virus Like Particles (VLPs) that contain these ZIKV proteins at their surface. The present invention provides means, in particular nucleic acids, vectors, cells and rescue systems to produce these recombinant infectious particles and VLPs. The present invention also relates to the use of these recombinant infectious particles and/or VLPs, in particular under the form of a composition, more particularly in a vaccine formulation, for the prevention of an infection by ZIKV or for the preventive protection against clinical outcomes of ZIKV infection.
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9.发明授权POLYPEPTIDES CHIMERIQUES ET LEURS APPLICATIONS THÉRAPEUTIQUES CONTRE UNE INFECTION À FLAVIVIRIDAE 有权CHIMÄRISCHEPOLYPEPTIDE UND IHRE THERAPEUTISCHE VERWENDUNG GEGEN FLAVIVIRIDAE-INFEKTIONEN
公开(公告)号：EP1893228B1
公开(公告)日：2016-03-23
申请号：EP06778626.9
申请日：2006-06-20
发明人： TANGY, Frédéric , LUCAS-HOURANI, Marianne , NAVARRO-SANCHEZ, Erika , FRENKIEL, Marie-Pascale , BEDOUELLE, Hugues , COMBREDET, Chantal , DESPRES, Philippe
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
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公开(公告)号：EP2598495A1
公开(公告)日：2013-06-05
申请号：EP11754491.6
申请日：2011-07-29
发明人： VIDALAIN, Pierre-Olivier , LUCAS-HOURANI, Marianne , TANGY, Frédéric , MUNIER-LEHMANN, Hélène , DAUZONNE, Daniel
IPC分类号： C07D307/82 , C07D307/83 , C07D405/04
CPC分类号： C07D307/83 , C07D307/82 , C07D405/02 , C07D405/04 , C07D493/04
摘要： The invention relates to compounds of formula (I) for use in the prevention and/or treatment of viral infections: Wherein X, Y, Z, T, R
1a and R
1b are as defined in claim 1.
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