发明公开
- 专利标题： ACTIVATORS OF HUMAN PYRUVATE KINASE
- 专利标题（中）： 激活剂人力丙酮酸激酶
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申请号： EP11730473.3申请日： 2011-04-26
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公开(公告)号： EP2563761A1公开(公告)日： 2013-03-06
- 发明人: BOXER, Matthew, B. , SHEN, Min , AULD, Douglas, S. , THOMAS, Craig, J. , WALSH, Martin, J.
- 申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 申请人地址： 6001 Executive Boulevard, Suite 325 Msc 7660 Bethesda, MD 20892-7660 US
- 专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： 6001 Executive Boulevard, Suite 325 Msc 7660 Bethesda, MD 20892-7660 US
- 代理机构： Pfenning, Meinig & Partner GbR
- 优先权： US329158P 20100429
- 国际公布： WO2011137089 20111103
- 主分类号： C07D209/30
- IPC分类号： C07D209/30 ; C07D215/36 ; C07D223/16 ; C07D265/36 ; A61K31/404 ; A61K31/4704 ; A61K31/538 ; A61K31/55 ; A61P35/00
摘要：
Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1-NR-L-A2 (I).
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