专利检索 ap:("The U.S.A. as represented by the Secretary, Department of Health AND Human Services") AND inv:"WALSH, Martin, J." 第 1 页

1.

发明公开
ACTIVATORS OF HUMAN PYRUVATE KINASE 审中-公开
标题翻译：激活剂人力丙酮酸激酶

公开(公告)号：EP2563761A1

公开(公告)日：2013-03-06

申请号：EP11730473.3

申请日：2011-04-26

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： BOXER, Matthew, B. , SHEN, Min , AULD, Douglas, S. , THOMAS, Craig, J. , WALSH, Martin, J.

IPC分类号： C07D209/30 , C07D215/36 , C07D223/16 , C07D265/36 , A61K31/404 , A61K31/4704 , A61K31/538 , A61K31/55 , A61P35/00

CPC分类号： C07D215/227 , C07D209/12 , C07D209/30 , C07D209/34 , C07D215/36 , C07D223/16 , C07D235/26 , C07D265/36

摘要： Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1-NR-L-A2 (I).