发明公开
- 专利标题： 1-HYDROXYIMINO-3-PHENYL-PROPANES
- 专利标题（中）： 1-羟基亚氨基-3-苯基 - 丙烷
-
申请号： EP11730660.5申请日： 2011-07-08
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公开(公告)号： EP2593426A1公开(公告)日： 2013-05-22
- 发明人: BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , MATTEI, Patrizio , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Klostermeyer-Rauber, Dörte
- 优先权： EP10169293 20100712
- 国际公布： WO2012007365 20120119
- 主分类号： C07C251/48
- IPC分类号： C07C251/48 ; C07D213/53 ; C07D213/55 ; C07D213/64 ; C07D213/89 ; C07D215/12 ; C07D239/26 ; C07D241/12
摘要：
This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula (I) wherein R
1 to R
10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.
1 to R
10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.
公开/授权文献
- EP2593426B1 1-HYDROXYIMINO-3-PHENYL-PROPANES 公开/授权日：2014-08-20
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