发明公开
EP2606057A2 MODIFIED 5' DIPHOSPHATE NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
有权
改进的5“二磷酸核苷和MADE的低聚物CONNECTIONS
- 专利标题： MODIFIED 5' DIPHOSPHATE NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
- 专利标题（中）： 改进的5“二磷酸核苷和MADE的低聚物CONNECTIONS
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申请号： EP11721849.5申请日： 2011-04-26
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公开(公告)号： EP2606057A2公开(公告)日： 2013-06-26
- 发明人: PRAKASH, Thazha, P. , SETH, Punit, P. , MANORHARAN, Muthiah , SWAYZE, Eric, E. , RAJEEV, Kallanthottathil, G. , ZLATEV, Ivan
- 申请人： Isis Pharmaceuticals, Inc. , Alnylam Pharmaceuticals, Inc.
- 申请人地址： 1896 Rutherford Road Carlsbad, CA 92008 US
- 专利权人： Isis Pharmaceuticals, Inc.,Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.,Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： 1896 Rutherford Road Carlsbad, CA 92008 US
- 代理机构： Warner, James Alexander
- 优先权： US329003P 20100428
- 国际公布： WO2011139695 20111110
- 主分类号： C07H19/10
- IPC分类号： C07H19/10
摘要：
Provided herein are modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom. More particularly, modified 5' diphosphate nucleosides are provided that can be further modified at the 2' and 5' positions. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The oligomeric compounds are also expected to be useful as primers and probes in diagnostic applications.
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