专利检索 ap:("Isis Pharmaceuticals, Inc." OR "Alnylam Pharmaceuticals, Inc.") AND inv:"MANORHARAN, Muthiah" 第 1 页

1.

发明公开
MODIFIED 5' DIPHOSPHATE NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM 有权
标题翻译：改进的5“二磷酸核苷和MADE的低聚物CONNECTIONS

公开(公告)号：EP2606057A2

公开(公告)日：2013-06-26

申请号：EP11721849.5

申请日：2011-04-26

申请人： Isis Pharmaceuticals, Inc. , Alnylam Pharmaceuticals, Inc.

发明人： PRAKASH, Thazha, P. , SETH, Punit, P. , MANORHARAN, Muthiah , SWAYZE, Eric, E. , RAJEEV, Kallanthottathil, G. , ZLATEV, Ivan

IPC分类号： C07H19/10

CPC分类号： C07H19/10 , C12N15/113

摘要： Provided herein are modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom. More particularly, modified 5' diphosphate nucleosides are provided that can be further modified at the 2' and 5' positions. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The oligomeric compounds are also expected to be useful as primers and probes in diagnostic applications.

2.

发明授权
MODIFIED 5' DIPHOSPHATE NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM 有权
标题翻译：改进的5“二磷酸核苷和MADE的低聚物CONNECTIONS

公开(公告)号：EP2606057B1

公开(公告)日：2016-06-15

申请号：EP11721849.5

申请日：2011-04-26

申请人： Ionis Pharmaceuticals, Inc. , Alnylam Pharmaceuticals, Inc.

发明人： PRAKASH, Thazha, P. , SETH, Punit, P. , MANORHARAN, Muthiah , SWAYZE, Eric, E. , RAJEEV, Kallanthottathil, G. , ZLATEV, Ivan

IPC分类号： C07H19/10

CPC分类号： C07H19/10 , C12N15/113