发明公开
EP2657251A1 Live, oral vaccine for protection against Shigella dysenteriae serotype 1
有权
Lebender，口服者Impfstoff gegen志贺氏志贺氏菌血清型1
- 专利标题： Live, oral vaccine for protection against Shigella dysenteriae serotype 1
- 专利标题（中）： Lebender，口服者Impfstoff gegen志贺氏志贺氏菌血清型1
-
申请号： EP13176694.1申请日： 2005-05-24
-
公开(公告)号： EP2657251A1公开(公告)日： 2013-10-30
- 发明人: Xu, DeQi , Kopecko, Dennis, J.
- 申请人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services
- 申请人地址： National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville,MD 20852-3804 US
- 专利权人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人地址： National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville,MD 20852-3804 US
- 代理机构： Vossius & Partner
- 优先权： US574279P 20040524; US609494P 20040913
- 主分类号： C07K14/25
- IPC分类号： C07K14/25 ; A61K39/112 ; C12N15/52
摘要：
The invention relates to an expression vector comprising a core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2; b) DNA encoding S. dysenteriae serotype 1 biosynthesis polypeptides encoded by any one of SEQ ID NOs: 1 and 2; c) DNA encoding variants of the polypeptide encoded by the DNA of (a) or (b), wherein the variants comprise O antigen biosynthesis polypeptide analogs, wherein one or more of the specified amino acids is deleted or replaced, or wherein one or more non-specified amino acids are added without loss of biosynthesis of Shigella dysenteriae serotype 1 O antigen or protective immunological activity of the O antigen biosynthesis gene product; and d) nucleic acid molecules encoding gene products that share at least about 90% sequence identity with the polypeptide encoded by the nucleic acid molecule of SEQ ID NO: 1 or 2.
公开/授权文献
信息查询
