公开(公告)号：EP4362981A1

公开(公告)日：2024-05-08

申请号：EP22834433.9

申请日：2022-06-30

申请人： Gigagen, Inc.

发明人： JOHNSON, David Scott ,  ADLER, Adam Shultz ,  MIZRAHI, Rena Aviva ,  LIM, Yoong Wearn ,  ASENSIO, Michael ,  STONE, Erica Lyn

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K14/25 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6806

CPC分类号： A61P35/00 ,  C07K16/2818 ,  C07K2317/7620130101 ,  C07K2317/2120130101 ,  C07K2317/3320130101 ,  C07K2317/1420130101 ,  C07K2317/56520130101 ,  C07K2317/9220130101 ,  C07K2317/9420130101 ,  C07K2317/9020130101 ,  C07K2317/4120130101 ,  C07K2317/52620130101 ,  C07K2317/73220130101 ,  C07K2317/3420130101 ,  A61K2039/50520130101 ,  A61K2039/50720130101 ,  A61K39/39591 ,  C07K2317/2420130101 ,  C07K2317/7120130101 ,  C07K2319/03520130101 ,  C07K2317/7420130101

公开(公告)号：EP3514168B1

公开(公告)日：2021-09-01

申请号：EP18207811.3

申请日：2015-06-10

发明人： POMA, Eric ,  WILLERT, Erin ,  HIGGINS, Jack ,  KIM, Jason

IPC分类号： C07K14/195 ,  C07K14/245 ,  C07K14/25 ,  C12N9/10 ,  C12N9/24 ,  C12N15/62

公开(公告)号：EP3868776A1

公开(公告)日：2021-08-25

申请号：EP21155849.9

申请日：2015-01-26

申请人： Molecular Templates, Inc.

发明人： POMA, Eric ,  WILLERT, Erin

IPC分类号： C07K14/245 ,  C07K14/25 ,  C07K14/195 ,  C12N15/62 ,  C12N15/31 ,  C12N9/10 ,  C12N9/24 ,  A61K39/00

摘要： The present invention is directed to T-cell epitope delivering polypeptides which deliver one or more CD8+ T-cell epitopes to the MHC class I presentation pathway of a cell, including toxin-derived polypeptides which comprise embedded T-cell epitopes and are de-immunized. The present invention provides cell-targeted, CD8+ T-cell epitope delivering molecules for the targeted delivery of cytotoxicity to certain cells, e.g., infected or malignant cells, for the targeted killing of specific cell types, and the treatment of a variety of diseases, disorders, and conditions, including cancers, immune disorders, and microbial infections. The present invention also provides methods of generating polypeptides capable of delivering one or more heterologous T-cell epitopes to the MHC class I presentation pathway, including polypeptides which are 1) B-cell and/or CD4+ T-cell de-immunized, 2) comprise embedded T-cell epitopes, and/or 3) comprises toxin effectors which retain toxin functions.

公开(公告)号：EP3253799B1

公开(公告)日：2020-12-02

申请号：EP16747275.2

申请日：2016-02-04

申请人： Molecular Templates, Inc.

发明人： POMA, Eric ,  WILLERT, Erin ,  KIM, Jason ,  HIGGINS, Jack ,  LIU, Jensing ,  FLORES-LEFRANC, Rodney

IPC分类号： C07K16/30 ,  C07K16/28 ,  C07K14/25

公开(公告)号：EP3099705A1

公开(公告)日：2016-12-07

申请号：EP15704153.4

申请日：2015-01-26

申请人： Molecular Templates, Inc.

发明人： POMA, Eric ,  WILLERT, Erin ,  ROBINSON, Garrett Lee ,  RAJAGOPALAN, Sangeetha ,  BRIESCHKE, Brigitte

IPC分类号： C07K14/25 ,  C07K14/245 ,  C12N15/62 ,  C12N15/31

CPC分类号： C07K14/25 ,  A61K2039/6037 ,  C07K14/245 ,  C07K16/00 ,  C07K16/085 ,  C07K16/088 ,  C07K16/1063 ,  C07K16/286 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/32 ,  C07K2319/04 ,  C07K2319/33 ,  C07K2319/40 ,  C07K2319/55 ,  C12N9/1077 ,  C12N9/2497 ,  C12N15/62 ,  C12Y204/02036 ,  C12Y302/02022 ,  Y02A50/489

摘要： The present invention is directed to T-cell epitope delivering polypeptides which deliver one or more CD8+ T-cell epitopes to the MHC class I presentation pathway of a cell, including toxin-derived polypeptides which comprise embedded T-cell epitopes and are de-immunized. The present invention provides cell-targeted, CD8+ T-cell epitope delivering molecules for the targeted delivery of cytotoxicity to certain cells, e.g., infected or malignant cells, for the targeted killing of specific cell types, and the treatment of a variety of diseases, disorders, and conditions, including cancers, immune disorders, and microbial infections. The present invention also provides methods of generating polypeptides capable of delivering one or more heterologous T-cell epitopes to the MHC class I presentation pathway, including polypeptides which are 1) B-cell and/or CD4+ T-cell de-immunized, 2) comprise embedded T-cell epitopes, and/or 3) comprises toxin effectors which retain toxin functions.

摘要翻译： 本发明涉及具有降低的抗原性和/或免疫原性潜力的志贺毒素效应物多肽。 免疫原性可以是对哺乳动物重复施用来自志贺毒素的蛋白质和多肽的限制。 本发明的志贺毒素效应物多肽具有用作治疗剂，诊断剂和免疫物质的组分的用途。 本发明的细胞毒性蛋白质具有用于选择性杀死特定细胞类型的用途以及用作治疗各种疾病（包括癌症，免疫紊乱和微生物感染）的治疗剂。 本发明的蛋白质还可用于检测特定细胞类型，收集诊断信息，并监测各种疾病（例如癌症，免疫紊乱和微生物感染）的治疗。

公开(公告)号：EP2728004A3

公开(公告)日：2014-07-23

申请号：EP14152631.9

申请日：2009-04-28

申请人： Idemitsu Kosan Co., Ltd. ,  National University Corporation Nara Institute of Science and Technology

发明人： Sawada, Kazutoshi ,  Yoshida, Kazuya ,  Matsui, Takeshi

IPC分类号： C12N15/09 ,  A01H5/00 ,  A61K39/106 ,  A61K39/108 ,  A61P31/04 ,  C07K14/245 ,  C07K14/25 ,  C07K14/28 ,  C07K19/00 ,  C12N5/10 ,  A61K39/112 ,  A61K39/00 ,  C12N15/82

CPC分类号： C07K14/245 ,  A61K39/00 ,  A61K39/0258 ,  A61K2039/517 ,  C07K14/25 ,  C07K14/28 ,  C07K2319/00 ,  C07K2319/55 ,  C12N15/8258 ,  Y02A50/472 ,  Y02A50/474

摘要： A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.

公开(公告)号：EP1979488A4

公开(公告)日：2009-05-27

申请号：EP07769138

申请日：2007-01-09

申请人： UNIV CALIFORNIA

发明人： KORNBLUTH RICHARD SYD ,  STONE GEOFFREY WILLIAM

IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/25 ,  C12N1/21

CPC分类号： A61K39/21 ,  A61K38/191 ,  A61K39/12 ,  A61K2039/5152 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2740/16134 ,  C12N2740/16234 ,  A61K2300/00

摘要： This invention discloses immunostimulatory combinations of Tumor Necrosis Factor Receptor Superfamily (TNFRSF) agonists, Toll-Like Receptor (TLR) agonists, "domain present in NA IP, C IITA, H ET-E, T P-1(NACHT)- L eucine R ich R epeat (LRR)" or "NLR" agonists, RIG-I-Like Helicase or "RLH" agonists, purinergic receptor agonists and cytokine/chemokine receptor agonists, together with delivery methods. The combinations, when used alone at the site of pathology, provide immunostimulation that induces host humoral and cellular immunologic responses to eliminate pathogens or neoplasms. Alternatively, when the combinations are used with a defined antigens, these combinations can induce focused humoral and cellular immunologic responses useful as prophylactic and/or ameliorative therapeutic modalities for infections and the treatment of neoplastic disorders.

公开(公告)号：EP2053058A1

公开(公告)日：2009-04-29

申请号：EP07291290.0

申请日：2007-10-24

申请人： Imperial Innovations Limited

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07K14/25

CPC分类号： C07K14/25 ,  A61K2039/522 ,  C07K16/1228

摘要： This application relates to compounds capable of inhibiting FNR transcription factor activity in a bacterial pathogen, methods of treating or preventing a pathogenic infection caused by a pathogenic bacteria by administering to a human, animal or plant said compounds, and methods of screening for compounds capable of inhibiting FNR transcription factor activity.

摘要翻译： 本申请涉及能够抑制细菌病原体中的FNR转录因子活性的化合物，通过向人，动物或植物施用所述化合物来治疗或预防致病菌引起的致病性感染的方法，以及筛选能够 抑制FNR转录因子活性。

公开(公告)号：EP1789532A1

公开(公告)日：2007-05-30

申请号：EP05769501.7

申请日：2005-08-04

申请人： Universita'Degli Studi di Roma "La Sapienza" ,  INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： BERNARDINI, Maria L. c/o Univ.degli Studi di Roma ,  SANSONETTI, J., Philippe

IPC分类号： C12N1/20 ,  C07K14/25 ,  A61K39/112

CPC分类号： A61K39/0283 ,  A61K2039/521 ,  C07K14/25 ,  C12N1/20 ,  Y02A50/476

摘要： Bacteria belonging to the Shigella genus, mutated to inactivate the function of at least one of the gene products responsible for the metabolism and/or recycling of the peptidoglycans of the cellular wall, for immunogenic use, especially mutated at SltY, MltA, MltB, ampG, amiA, MppA genes, and immunogenic compositions comprising them.

公开(公告)号：EP1355928B1

公开(公告)日：2007-05-16

申请号：EP02700240.1

申请日：2002-02-01

申请人： Institut Curie ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Institut National de la Santé et de la Recherche Médicale ,  Université Pierre et Marie Curie (Paris VI)

发明人： JOHANNES, Ludger ,  TARTOUR, Eric ,  GOUD, Bruno ,  FRIDMAN, Wolf, Hervé

IPC分类号： C07K14/25 ,  C07K19/00 ,  C07K17/00 ,  C12N15/31 ,  C12N1/21 ,  C12Q1/68 ,  A61K48/00 ,  A61K38/16

CPC分类号： A61K39/385 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/6037 ,  A61K2039/627 ,  C07K14/25 ,  C07K2319/00

摘要： The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine. p