发明公开
EP2658997A1 A METHOD TO IDENTIFY ASYMPTOMATIC HIGH-RISK INDIVIDUALS WITH EARLY STAGE LUNG CANCER BY MEANS OF DETECTING miRNAs IN BIOLOGIC FLUIDS
审中-公开
一种用于识别有很多高危患者肺癌问题早发现通过生物体液的miRNA
- 专利标题： A METHOD TO IDENTIFY ASYMPTOMATIC HIGH-RISK INDIVIDUALS WITH EARLY STAGE LUNG CANCER BY MEANS OF DETECTING miRNAs IN BIOLOGIC FLUIDS
- 专利标题（中）： 一种用于识别有很多高危患者肺癌问题早发现通过生物体液的miRNA
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申请号： EP11807925.0申请日： 2011-12-22
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公开(公告)号： EP2658997A1公开(公告)日： 2013-11-06
- 发明人: BIANCHI, Fabrizio , NICASSIO, Francesco , MARZI, Matteo Jacopo Luca Nicolò , DI FIORE, Pierpaolo
- 申请人： IFOM Fondazione Istituto Firc di Oncologia Molecolare , Instituto Europeo di Oncologia S.r.l. , Universita' degli Studi di Milano
- 申请人地址： Via Adamello 16 20139 Milano IT
- 专利权人： IFOM Fondazione Istituto Firc di Oncologia Molecolare,Instituto Europeo di Oncologia S.r.l.,Universita' degli Studi di Milano
- 当前专利权人： IFOM Fondazione Istituto Firc di Oncologia Molecolare,Instituto Europeo di Oncologia S.r.l.,Universita' degli Studi di Milano
- 当前专利权人地址： Via Adamello 16 20139 Milano IT
- 代理机构： Capasso, Olga
- 优先权： US201061428363P 20101230; EP11160387 20110330
- 国际公布： WO2012089630 20120705
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
A diagnostic and/or prognostic model of at least 5 serum miRNAs selected among a group of 34 miRNAs that identifies subjects with early stage lung cancer, namely non-small cell lung carcinomas (NSCLCs), in a population of asymptomatic high-risk individuals, with 80% accuracy. The model could also distinguish between benign and malignant lesions and is sensitive enough to capture the disease onset. In addition, the model could also diagnose or confirm a diagnosis of lung cancer in symptomatic patients, and monitor the lung tumor status after treatment with surgery and/or chemotherapy and/or radiotherapy in a subject with such lung cancer.
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