公开(公告)号：EP2658997A1

公开(公告)日：2013-11-06

申请号：EP11807925.0

申请日：2011-12-22

申请人： IFOM Fondazione Istituto Firc di Oncologia Molecolare ,  Instituto Europeo di Oncologia S.r.l. ,  Universita' degli Studi di Milano

发明人： BIANCHI, Fabrizio ,  NICASSIO, Francesco ,  MARZI, Matteo Jacopo Luca Nicolò ,  DI FIORE, Pierpaolo

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/16 ,  C12Q2600/178

摘要： A diagnostic and/or prognostic model of at least 5 serum miRNAs selected among a group of 34 miRNAs that identifies subjects with early stage lung cancer, namely non-small cell lung carcinomas (NSCLCs), in a population of asymptomatic high-risk individuals, with 80% accuracy. The model could also distinguish between benign and malignant lesions and is sensitive enough to capture the disease onset. In addition, the model could also diagnose or confirm a diagnosis of lung cancer in symptomatic patients, and monitor the lung tumor status after treatment with surgery and/or chemotherapy and/or radiotherapy in a subject with such lung cancer.

摘要翻译： 至少5种血清miRNA的一种诊断和/或预后模型的一组34种miRNA识别与早期肺癌，即非小细胞肺癌（非小细胞肺癌）的受试者，在无症状的高风险的个体的群体中选择的， 准确80％。 因此，该模型能够良性和恶性病变区分和足够敏感地捕捉到了疾病发作。 此外，该模型可因此诊断或确认肺癌的症状的患者诊断，和监控与肺癌的受试者检查外科手术和/或化学疗法和/或放射疗法治疗后的肺肿瘤的状态。

公开(公告)号：EP3191602A1

公开(公告)日：2017-07-19

申请号：EP15759820.2

申请日：2015-09-09

申请人： Istituto Europeo di Oncologia S.r.l. ,  IFOM Fondazione Istituto Firc di Oncologia Molecolare ,  Universita' degli Studi di Milano

发明人： DI FIORE, Pier Paolo ,  BIANCHI, Fabrizio ,  NICASSIO, Francesco ,  MARZI, Matteo, Jacopo, Luca, Nicolo ,  MONTANI, Francesca

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/16 ,  G06F19/18

摘要： The disclosure describes a method for diagnosing lung cancer in a subject by detecting in a biological sample obtained from that patient a miRNA signature, the presence of which provides an earlier indication of cancer than alternative art-recognized methods, including, but not limited to, low-dose computed tomography (LDCT).

摘要翻译： 本公开描述了用于通过检测从患者获得的生物样品中的miRNA标记来诊断受试者中的肺癌的方法，所述miRNA标记的存在比替代的本领域公认的方法提供更早的癌症指征，包括但不限于， 低剂量计算机断层扫描（LDCT）。

公开(公告)号：EP1802971A2

公开(公告)日：2007-07-04

申请号：EP05787481.0

申请日：2005-09-20

申请人： IFOM Fondazione Istituto Firc di Oncologia Molecolare

发明人： DI FIORE, Pier, Paolo ,  SALVATORE, Pece ,  BONAPACE, Ian, Marc ,  NICASSIO, Francesco ,  BIANCHI, Fabrizio ,  VECCHI, Manuela, IFOM, Istituto FIRC di Oncologia ,  CONFALONIERI, Stefano,IFOM, Istituto FIRC

IPC分类号： G01N33/50 ,  G01N33/574

CPC分类号： G01N33/57415 ,  G01N2333/723

摘要： The invention relates to methods of diagnosis and prognosis of cancer, the methods comprising determining the level of one or more gene products. In addition, the invention relates to modulators of the gene products for use in treatment of cancer. The genes include E1A-induced genes and Numb.