发明公开
EP2679580A1 THIOAMIDE COMPOUND, METHOD FOR PRODUCING THIOAMIDE COMPOUND, METHOD FOR PRODUCING [(4R,6R)-6-AMINOETHYL-1,3-DIOXANE-4-YL]ACETATE DERIVATIVE, AND METHOD FOR PRODUCING ATORVASTATIN
有权
硫代酰胺，用于生产硫代酰胺，用于生产[（4 R，6 R）] - 6-氨基乙基-1,3-二恶烷-4-基] -ACETATDERIVATEN AND PROCESS FOR PRODUCING阿托伐他汀
- 专利标题： THIOAMIDE COMPOUND, METHOD FOR PRODUCING THIOAMIDE COMPOUND, METHOD FOR PRODUCING [(4R,6R)-6-AMINOETHYL-1,3-DIOXANE-4-YL]ACETATE DERIVATIVE, AND METHOD FOR PRODUCING ATORVASTATIN
- 专利标题（中）： 硫代酰胺，用于生产硫代酰胺，用于生产[（4 R，6 R）] - 6-氨基乙基-1,3-二恶烷-4-基] -ACETATDERIVATEN AND PROCESS FOR PRODUCING阿托伐他汀
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申请号： EP12750077.5申请日： 2012-02-14
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公开(公告)号： EP2679580A1公开(公告)日： 2014-01-01
- 发明人: SHIBASAKI, Masakatsu , KUMAGAI, Naoya
- 申请人： Microbial Chemistry Research Foundation
- 申请人地址： 14-23, Kamiosaki 3-chome Shinagawa-ku Tokyo 141-0021 JP
- 专利权人： Microbial Chemistry Research Foundation
- 当前专利权人： Microbial Chemistry Research Foundation
- 当前专利权人地址： 14-23, Kamiosaki 3-chome Shinagawa-ku Tokyo 141-0021 JP
- 代理机构： Graf von Stosch, Andreas
- 优先权： JP2011035006 20110221
- 国际公布： WO2012114926 20120830
- 主分类号： C07C327/42
- IPC分类号： C07C327/42 ; A61K31/40 ; A61P3/06 ; A61P13/08 ; A61P19/10 ; A61P25/28 ; C07D207/34 ; C07F7/18 ; C07B61/00
摘要：
A thioamide compound represented by the following general formula (1):
wherein, in the general formula (1), R 1 represents one of -OR 11 and -NR 12 R 13 ; R 2 and R 3 each independently represent one of a protecting group of an amide group and a hydrogen atom; the R 11 represents one of a protecting group of a hydroxyl group and a hydrogen atom; and the R 12 and R 13 each independently represent one of a protecting group of an amino group and a hydrogen atom, where the R 12 and R 13 may together form a protecting group having a cyclic structure.
wherein, in the general formula (1), R 1 represents one of -OR 11 and -NR 12 R 13 ; R 2 and R 3 each independently represent one of a protecting group of an amide group and a hydrogen atom; the R 11 represents one of a protecting group of a hydroxyl group and a hydrogen atom; and the R 12 and R 13 each independently represent one of a protecting group of an amino group and a hydrogen atom, where the R 12 and R 13 may together form a protecting group having a cyclic structure.
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