发明公开
EP2714684A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES
审中-公开
成分与链接多拉司他汀衍生物非天然氨基酸和方法含有这些物质及其用途
- 专利标题： COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES
- 专利标题（中）： 成分与链接多拉司他汀衍生物非天然氨基酸和方法含有这些物质及其用途
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申请号： EP12793246.5申请日： 2012-05-24
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公开(公告)号： EP2714684A1公开(公告)日： 2014-04-09
- 发明人: MIAO, Zhenwei , ATKINSON, Kyle, C. , BIROC, Sandra , BUSS, Timothy , COOK, Melissa , KRAYNOV, Vadim , MARSDEN, Robin , PINKSTAFF, Jason , SKIDMORE, Lillian , SUN, Ying , SZYDLIK, Angieszka , LOPEZ DE VALENTA, Ianina
- 申请人： Ambrx, Inc.
- 申请人地址： 10975 North Torrey Pines Road, Suite 100 La Jolla, CA 92037 US
- 专利权人： Ambrx, Inc.
- 当前专利权人： Ambrx, Inc.
- 当前专利权人地址： 10975 North Torrey Pines Road, Suite 100 La Jolla, CA 92037 US
- 代理机构： Hallybone, Huw George
- 优先权： US201161491146P 20110527
- 国际公布： WO2012166560 20121206
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; C07D207/08 ; C07D401/12 ; A61K31/427 ; A61P35/00
摘要：
Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
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