发明公开
EP2731960A1 IN VITRO ASSESSMENT OF CARDIOVASCULAR EVENTS BY ASSAY FOR NEO-EPITOPES OF TITIN PROTEIN
有权
体外评估根据测试心血管事件的新表位的肌联蛋白蛋白质
- 专利标题： IN VITRO ASSESSMENT OF CARDIOVASCULAR EVENTS BY ASSAY FOR NEO-EPITOPES OF TITIN PROTEIN
- 专利标题（中）： 体外评估根据测试心血管事件的新表位的肌联蛋白蛋白质
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申请号： EP12731501.8申请日： 2012-07-06
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公开(公告)号： EP2731960A1公开(公告)日： 2014-05-21
- 发明人: LEEMING, Diana Julie , KARSDAL, Morten , VASSILIADIS, Efstathios
- 申请人： Nordic Bioscience A/S
- 申请人地址： Herlev Hovedgade 207 2730 Herlev DK
- 专利权人： Nordic Bioscience A/S
- 当前专利权人： Nordic Bioscience A/S
- 当前专利权人地址： Herlev Hovedgade 207 2730 Herlev DK
- 代理机构： Beck Greener
- 优先权： GB201111788 20110711
- 国际公布： WO2013007643 20130117
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C07K16/18 ; G01N33/68
摘要：
A bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a titin protein by a proteinase comprises contacting a sample with an antibody specifically binding said neo-epitope and determining the level of binding. Partial sequences of titin that may be detected include: 3519' ↓GEYVCDCGTD '13528, 3532' NVTVEARLIK↓ '13542, 3543'↓VEKPLYGVEV '1553.
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