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公开(公告)号：EP3173792A3
公开(公告)日：2017-07-05
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprising conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising:
contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and
measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV,
collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.-
公开(公告)号：EP2715360A1
公开(公告)日：2014-04-09
申请号：EP12723653.7
申请日：2012-05-23
IPC分类号： G01N33/564
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/564 , G01N33/6842 , G01N2333/78 , G01N2800/102
摘要： An assay for citrullinated fragments of SOCS-2, Alpha 1 anti tyrpsin, versican, biglycan, laminin, or other protein having a terminal antibody binding site comprising citrulline in a blood derived sample shows diagnostic relevance in relation to rheumatoid arthritis or fibrotic disease.
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3.发明授权IN VITRO ASSESSMENT OF CARDIOVASCULAR EVENTS BY ASSAY FOR NEO-EPITOPES OF TITIN PROTEIN 有权体外评估根据测试心血管事件的新表位的肌联蛋白蛋白质
公开(公告)号：EP2731960B1
公开(公告)日：2016-11-16
申请号：EP12731501.8
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
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公开(公告)号：EP2414844B1
公开(公告)日：2014-12-10
申请号：EP10715752.1
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.
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公开(公告)号：EP2414844A2
公开(公告)日：2012-02-08
申请号：EP10715752.1
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/37 , G01N2333/4737 , G01N2333/78 , G01N2800/085 , G01N2800/32 , G01N2800/50
摘要： Methods of diagnosis or of quantitation of fibrosis comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of fibrosis. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein said protein is collagen type III, collagen type I, collagen type IV, collagen type V, or collagen type VI, elastin, biglycan, decorin, lumican, versican, perlecan, neurocan, brevican, fibromodulin, serglycin, syndecan, betaglycan, vimentin, or C-reactive protein.
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公开(公告)号：EP3590959A2
公开(公告)日：2020-01-08
申请号：EP19188754.6
申请日：2012-07-18
发明人： VEIDAL, Sanne , KARSDAL, Morten Asser , LEEMING, Diana Julie , BARASCUK, Natasha , SKJOT-ARKIL, Helene , VASSILIADIS, Efstathios
摘要： Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of pathology. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope. Neo-epitopes from, collagen type I, collagen type III, collagen type IV, collagen type V, collagen type VI, elastin, biglycan, decorin, lumican, versican, C-reactive protein, ApoE and laminins are described.
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公开(公告)号：EP3173792B1
公开(公告)日：2019-06-12
申请号：EP16205956.2
申请日：2010-03-29
申请人： Nordic Bioscience A/S , Novartis AG
发明人： VEIDAL, Sanne , KARSDAL, Morten , LEEMING, Diana Julie , BARASCUK MICHAELSEN, Natasha , SKJOT-ARKIL, Helene , SEGOVIA-SILVESTRE, Antonio , VASSILIADIS, Efstathios
IPC分类号： G01N33/68
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公开(公告)号：EP3239173A3
公开(公告)日：2018-01-24
申请号：EP17172678.9
申请日：2012-07-18
发明人： VEIDAL, Sanne, Skovgård , KARSDAL, Morten Asser , LEEMING, Diana J. , BARASCUK, Natasha , SKJOT-ARKIL, Helene , VASSILIADIS, Efstathios
CPC分类号： G01N33/6893 , C07K14/78 , C12Q1/37 , G01N2333/4737 , G01N2333/775 , G01N2333/78 , G01N2800/32
摘要： Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of pathology. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope. Neo-epitopes from, collagen type I, collagen type III, collagen type IV, collagen type V, collagen type VI, elastin, biglycan, decorin, lumican, versican, C-reactive protein, ApoE and laminins are described.
摘要翻译： 诊断或定量病理状况的方法包括进行免疫测定以测量天然存在于bioflui样品中的含有新表位的蛋白质片段，并且将所述患者中的所述测量值在正常水平以上的升高与病理的存在或程度相关联。 所述免疫测定法通过包括以下步骤的方法进行：使天然存在于所述样品中的蛋白质片段与免疫学结合配偶体接触，所述免疫学结合配偶体与通过蛋白酶裂解蛋白质形成的新表位反应并测量肽片段与所述免疫学结合的结合程度 在其中测量包含所述新表位的蛋白质片段。 描述了来自I型胶原蛋白，III型胶原蛋白，IV型胶原蛋白，V型胶原蛋白，VI型胶原蛋白，弹性蛋白，双糖链蛋白聚糖，核心蛋白聚糖，lumican，多功能蛋白聚糖，C-反应蛋白，ApoE和层粘连蛋白的新表位。
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公开(公告)号：EP2734542B1
公开(公告)日：2018-12-26
申请号：EP12740115.6
申请日：2012-07-18
发明人： VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJØT-ARKIL, Helene , VASSILIADIS, Efstathios
CPC分类号： G01N33/6893 , C07K14/78 , C12Q1/37 , G01N2333/4737 , G01N2333/775 , G01N2333/78 , G01N2800/32
摘要： Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of pathology. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope. Neo-epitopes from, collagen type I, collagen type III, collagen type IV, collagen type V, collagen type VI, elastin, biglycan, decorin, lumican, versican, C-reactive protein, ApoE and laminins are described.
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公开(公告)号：EP2734542A2
公开(公告)日：2014-05-28
申请号：EP12740115.6
申请日：2012-07-18
发明人： VEIDAL, Sanne S. , KARSDAL, Morten A. , LEEMING, Diana J. , BARASCUK, Natasha , SKJØT-ARKIL, Helene , VASSILIADIS, Efstathios
CPC分类号： G01N33/6893 , C07K14/78 , C12Q1/37 , G01N2333/4737 , G01N2333/775 , G01N2333/78 , G01N2800/32
摘要： Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of pathology. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope. Neo-epitopes from, collagen type I, collagen type III, collagen type IV, collagen type V, collagen type VI, elastin, biglycan, decorin, lumican, versican, C-reactive protein, ApoE and laminins are described.
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