发明公开
- 专利标题： NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS
- 专利标题（中）： 新的大环因子XIA抑制剂
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申请号： EP12762427.8申请日： 2012-08-06
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公开(公告)号： EP2739628A1公开(公告)日： 2014-06-11
- 发明人: PINTO, Donald J. , CORTE, James R. , GILLIGAN, Paul J. , FANG, Tianan , SMITH II, Leon M. , WANG, Yufeng , YANG, Wu , EWING, William R.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Post Office Box 4000 Route 206 and Province Line Road Princeton, NJ 05843-4000 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Post Office Box 4000 Route 206 and Province Line Road Princeton, NJ 05843-4000 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US201161515401P 20110805
- 国际公布： WO2013022818 20130214
- 主分类号： C07D487/08
- IPC分类号： C07D487/08 ; A61K31/395
摘要：
The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
公开/授权文献
- EP2739628B1 NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS 公开/授权日：2017-06-07
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