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公开(公告)号：EP3099686B1
公开(公告)日：2020-03-11
申请号：EP15705428.9
申请日：2015-01-30
发明人： CORTE, James R. , DE LUCCA, Indawati , FANG, Tianan , YANG, Wu , WANG, Yufeng , DILGER, Andrew K. , PABBISETTY, Kumar Balashanmuga , EWING, William R. , ZHU, Yeheng , WEXLER, Ruth R. , PINTO, Donald J. P. , ORWAT, Michael J. , SMITH II, Leon M.
IPC分类号： C07D471/08 , C07D487/08 , A61K31/529 , A61P7/00
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公开(公告)号：EP2880026B1
公开(公告)日：2017-02-22
申请号：EP13747625.5
申请日：2013-08-02
发明人： YANG, Wu , CORTE, James, R. , GILLIGAN, Paul, J. , PINTO, Donald, J.P., Pinto , EWING, William, R. , DILGER, Andrew, K. , WANG, Yufeng , FANG, Tianan , PABBISETTY, Kumar, B. , SMITH II, Leon, M.
IPC分类号： C07D401/04 , C07D471/08 , C07D487/08 , C07D487/18 , A61K31/439 , A61P7/00
CPC分类号： C07D471/08 , C07C53/18 , C07D401/04 , C07D471/18 , C07D487/08 , C07D487/18 , C07H17/02
摘要： The present invention provides compounds of Formula (X):(Formula (X), or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：EP3089979A1
公开(公告)日：2016-11-09
申请号：EP15747721.7
申请日：2015-07-29
发明人： DILGER, Andrew K. , CORTE, James R. , DE LUCCA, Indawati , FANG, Tianan , WU, Yang , WANG, Yufeng , PABBISETTY, Kumar Balashanmuga , EWING, William R. , ZHU, Yeheng , WEXLER, Ruth R. , PINTO, Donald J.P. , ORWAT, Michael J. , SMITH II, Leon M.
IPC分类号： C07D471/18 , A61K31/4162 , A61P7/02
CPC分类号： C07D471/18
摘要： The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 本发明提供式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：EP2739628A1
公开(公告)日：2014-06-11
申请号：EP12762427.8
申请日：2012-08-06
发明人： PINTO, Donald J. , CORTE, James R. , GILLIGAN, Paul J. , FANG, Tianan , SMITH II, Leon M. , WANG, Yufeng , YANG, Wu , EWING, William R.
IPC分类号： C07D487/08 , A61K31/395
CPC分类号： C07D519/00 , C07D471/06 , C07D471/08 , C07D487/06 , C07D487/08 , C07D498/06 , C07D498/08
摘要： The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：EP1951675B1
公开(公告)日：2013-03-20
申请号：EP06836442.1
申请日：2006-10-19
发明人： YANG, Wu , WANG, Yufeng , KICK, Ellen, K.
IPC分类号： C07D409/12
CPC分类号： C07D217/26 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
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公开(公告)号：EP1951690B1
公开(公告)日：2012-03-28
申请号：EP06846347.0
申请日：2006-11-20
发明人： YANG, Wu , WANG, Yufeng
IPC分类号： C07D249/08 , C07D277/42 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D491/04 , A61K31/41 , A61K31/435 , C07C233/12 , A61P3/00 , A61P9/00
CPC分类号： C07D417/12 , C07D249/08 , C07D277/42 , C07D401/12 , C07D403/12 , C07D471/04 , C07D491/04
摘要： Compounds of formula (Ia) and (Ib): wherein A, B, C and Rl are described herein, are suitable as cholesteryl ester transfer protein (CETP) inhibitors.
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公开(公告)号：EP4286372A2
公开(公告)日：2023-12-06
申请号：EP23185426.6
申请日：2015-07-29
发明人： DILGER, Andrew K. , CORTE, James R. , DE LUCCA, Indawati , FANG, Tianan , YANG, Wu , WANG, Yufeng , PABBISETTY, Kumar Balashanmuga , EWING, Willam R. , ZHU, Yeheng , WEXLER, Ruth R. , PINTO, Donald J.P. , ORWAT, Michael J. , SMITH II, Leon M.
IPC分类号： C07D239/34
摘要： The present invention provides a compound which is (9 R ,13 S )-13-{4-[5-chloro-2-(4-chloro-1 H -1,2,3-triazol-1-yl)phenyl]-6-oxo-1,6-dihydropyrimidin-1-yl}-3-(difluoromethyl)-9-methyl-3,4,7,15-tetraazatricyclo[12.3.1.0 2,6 ]octadeca-1(18),2(6),4,14,16-pentaen-8-one trifluoroacetate, or a stereoisomer or tautomer thereof. This invention also relates to pharmaceutical compositions comprising this compound and their use in the treatment of thromboembolic disorders.
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公开(公告)号：EP3293186B1
公开(公告)日：2020-09-23
申请号：EP17189935.4
申请日：2015-07-29
发明人： DILGER, Andrew K. , CORTE, James R. , DE LUCCA, Indawati , FANG, Tianan , YANG, Wu , WANG, Yufeng , PABBISETTY, Kumar Balashanmuga , EWING, William R. , ZHU, Yeheng , WEXLER, Ruth R. , PINTO, Donald J.P. , ORWAT, Michael J. , SMITH II, Leon M.
IPC分类号： C07D471/18 , A61K31/4162 , A61P7/02
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9.发明公开
公开(公告)号：EP3099688A1
公开(公告)日：2016-12-07
申请号：EP15705427.1
申请日：2015-01-30
发明人： DILGER, Andrew, K. , CORTE, James, R. , DE LUCCA, Indawati , FANG, Tianan , YANG, Wu , WANG, Yufeng , PABBISETTY, Kumar Balashanmuga , EWING, William, R. , ZHU, Yeheng , WEXLER, Ruth, R. , PINTO, Donald, J.P. , ORWAT, Michael, J. , SMITH II, Leon, M.
IPC分类号： C07D471/18 , C07D487/08 , A61K31/439 , A61P9/10
CPC分类号： C07D471/18 , C07D487/08
摘要： The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 本发明提供式（Ia）化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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10.发明公开MACROCYCLES WITH AROMATIC P2' GROUPS AS FACTOR XIA INHIBITORS 审中-公开麻黄碱麻醉药亚麻油P2'-GRUPPEN ALS FAKTOR-XIA-HEMMER
公开(公告)号：EP3099686A1
公开(公告)日：2016-12-07
申请号：EP15705428.9
申请日：2015-01-30
发明人： CORTE, James R. , DE LUCCA, Indawati , FANG, Tianan , YANG, Wu , WANG, Yufeng , DILGER, Andrew K. , PABBISETTY, Kumar Balashanmuga , EWING, William R. , ZHU, Yeheng , WEXLER, Ruth R. , PINTO, Donald J. P. , ORWAT, Michael J. , SMITH II, Leon M.
IPC分类号： C07D471/08 , C07D487/08 , A61K31/529 , A61P7/00
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译： 本发明提供式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或FXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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