发明公开
EP2740724A1 COMPOUND FOR TREATING CARTILAGE DISORDERS
有权
VERBINDUNG ZUR BEHANDLUNG VON KNORPELERKRANKUNGEN
- 专利标题: COMPOUND FOR TREATING CARTILAGE DISORDERS
- 专利标题(中): VERBINDUNG ZUR BEHANDLUNG VON KNORPELERKRANKUNGEN
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申请号: EP12822308.8申请日: 2012-08-03
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公开(公告)号: EP2740724A1公开(公告)日: 2014-06-11
- 发明人: OBITSU, Tetsuo , TANI, Kousuke , SUGIHARA, Hikaru , NISHIURA, Akio , FUJIMURA, Shinsei
- 申请人: ONO Pharmaceutical Co., Ltd.
- 申请人地址: 1-5, Doshomachi 2-chome Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 专利权人: ONO Pharmaceutical Co., Ltd.
- 当前专利权人: ONO Pharmaceutical Co., Ltd.
- 当前专利权人地址: 1-5, Doshomachi 2-chome Chuo-ku Osaka-shi, Osaka 541-8526 JP
- 代理机构: Jones, Nicholas Andrew
- 优先权: JP2011172082 20110805
- 国际公布: WO2013021935 20130214
- 主分类号: C07C405/00
- IPC分类号: C07C405/00 ; A61K9/10 ; A61K31/5575 ; A61K47/10 ; A61K47/26 ; A61K47/34 ; A61K47/36 ; A61K47/40 ; A61K47/44 ; A61P19/08 ; C07C69/732 ; C07C69/92 ; C07C235/16
摘要:
The present invention provides a compound of which active form is represented by a formula (A). and which can be injected into a joint cavity which is an affected part of disorders and can be accumulated in the joint cavity to exert the pharmacological effect thereof in a sustained manner, for the purpose of ameliorating cartilage disorders without developing any side effect. A compound according to the present invention, which is represented by a formula (I):
(wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective preventive and/or therapeutic agent for cartilage disorders. Since a suspension produced using this compound can be injected without requiring the incision of the affected part, it can reduce the burden on patients, and is extremely useful as a medicinal agent.
(wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective preventive and/or therapeutic agent for cartilage disorders. Since a suspension produced using this compound can be injected without requiring the incision of the affected part, it can reduce the burden on patients, and is extremely useful as a medicinal agent.
公开/授权文献
- EP2740724B1 COMPOUND FOR TREATING CARTILAGE DISORDERS 公开/授权日:2016-12-28
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