发明授权
- 专利标题： NO- AND H2S- RELEASING COMPOUNDS
- 专利标题（中）： NO-和H2S释放化合物
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申请号： EP12824542.0申请日： 2012-08-15
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公开(公告)号： EP2744487B1公开(公告)日： 2016-10-05
- 发明人: KASHFI, Khosrow , KODELA, Ravinder
- 申请人： Research Foundation Of The City University Of New York
- 申请人地址： 230 West 41st Street New York, NY 10036 US
- 专利权人： Research Foundation Of The City University Of New York
- 当前专利权人： Research Foundation Of The City University Of New York
- 当前专利权人地址： 230 West 41st Street New York, NY 10036 US
- 代理机构： V.O.
- 优先权： US201161523513P 20110815; US201261615700P 20120326; US201261635624P 20120419
- 国际公布： WO2013025790 20130221
- 主分类号： A61K31/385
- IPC分类号： A61K31/385 ; C07D339/04 ; A61P29/00
摘要：
This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
公开/授权文献
- EP2744487A2 NO- AND H2S- RELEASING COMPOUNDS 公开/授权日：2014-06-25
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