发明公开
EP2763696A2 IDENTIFICATION AND ATTENUATION OF THE IMMUNOSUPPRESSIVE DOMAINS IN FUSION PROTEINS OF ENVELOPED RNA VIRUSES 审中-公开
识别和免疫畴的损失融合蛋白包膜RNA病毒

  • 专利标题: IDENTIFICATION AND ATTENUATION OF THE IMMUNOSUPPRESSIVE DOMAINS IN FUSION PROTEINS OF ENVELOPED RNA VIRUSES
  • 专利标题(中): 识别和免疫畴的损失融合蛋白包膜RNA病毒
  • 申请号: EP12781027.3
    申请日: 2012-10-05
  • 公开(公告)号: EP2763696A2
    公开(公告)日: 2014-08-13
  • 发明人: RYTTERGÅRD DUCH, MogensBAHRAMI, Shervin
  • 申请人: Skau Aps
  • 申请人地址: Åbogade 15 8200 Aarhus N DK
  • 专利权人: Skau Aps
  • 当前专利权人: Skau Aps
  • 当前专利权人地址: Åbogade 15 8200 Aarhus N DK
  • 代理机构: Poulsen, Niels Jakob
  • 优先权: DK201170564 20111007; US201161544441P 20111007
  • 国际公布: WO2013050048 20130411
  • 主分类号: A61K39/12
  • IPC分类号: A61K39/12 C07K4/02 C07K14/08
IDENTIFICATION AND ATTENUATION OF THE IMMUNOSUPPRESSIVE DOMAINS IN FUSION PROTEINS OF ENVELOPED RNA VIRUSES
摘要:
The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.
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