摘要:
The present invention refers to the medical field. Particularly, it refers to a method for determining whether an immune response has occurred in subjects who have been infected with- or vaccinated against coronavirus.
摘要:
Die Erfindung beschreibt zwei immunogene Regionen des E7-Proteins von Humanen Papillomvirus Typ 16 (HPV 16), wobei die eine immunreaktive Region stromabwärts von Nukleotid 595 und die andere stromabwärts von Nukleotid 667 des HPV 16 Genoms lokalisiert ist.
摘要:
Die Erfindung beschreibt zwei immunogene Regionen des E7-Proteins von Humanen Papillomvirus Typ 16 (HPV 16), wobei die eine immunreaktive Region stromabwärts von Nukleotid 595 und die andere stromabwärts von Nukleotid 667 des HPV 16 Genoms lokalisiert ist.
摘要:
The invention is directed to peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides of the present invention are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The invention is further directed to peptides referred to as the Lytic Base Unit (LBU) peptides derived from the LLP1 analogs, also having antimicrobial activity. In addition, the present invention is also directed to methods of using the peptides in a variety of contexts, including the treatment of prevention of infectious diseases. The antimicrobial LLP1 analog peptides and the LBU peptides (collectively eLLPs) may be highly active under high salt conditions and in biologic fluids. In addition, the eLLPs are effective when presented either in soluble form, or when attached to a solid surface. Furthermore, the peptides of the present invention are selectively active against a wide variety of bacterial pathogens and exhibit minimal toxicity to eukaryotic cells in vitro and in vivo.
摘要:
The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.