发明公开
EP2771311A1 PROCESS FOR THE PREPARATION OF OSELTAMIVIR AND METHYL 3-EPI-SHIKIMATE
审中-公开
VERFAHREN ZUR HERSTELLUNG VON OSELTAMIVIR UND METHYL-3-EPI-SHIKIMAT
- 专利标题： PROCESS FOR THE PREPARATION OF OSELTAMIVIR AND METHYL 3-EPI-SHIKIMATE
- 专利标题（中）： VERFAHREN ZUR HERSTELLUNG VON OSELTAMIVIR UND METHYL-3-EPI-SHIKIMAT
-
申请号： EP12806709.7申请日： 2012-10-25
-
公开(公告)号： EP2771311A1公开(公告)日： 2014-09-03
- 发明人: RAWAT, Varun , DEY, Soumen , ARUMUGAM, Sudalai
- 申请人： Council of Scientific & Industrial Research
- 申请人地址： Anusandhan Bhawan Rafi Marg New Delhi 110 001 IN
- 专利权人： Council of Scientific & Industrial Research
- 当前专利权人： Council of Scientific & Industrial Research
- 当前专利权人地址： Anusandhan Bhawan Rafi Marg New Delhi 110 001 IN
- 代理机构： Graf von Stosch, Andreas
- 优先权： INDE30392011 20111025
- 国际公布： WO2013061340 20130502
- 主分类号： C07C231/12
- IPC分类号： C07C231/12 ; C07C231/18 ; C07C247/14 ; C07D203/26 ; C07D303/06 ; C07D303/40 ; C07F7/18
摘要：
The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (−)-methyl 3-epi-shikimate.
信息查询
