发明公开
EP2773696A1 SELF-ASSEMBLED COMPOSITE ULTRASMALL PEPTIDE-POLYMER HYDROGELS
有权
聚合物 - 聚合物 - 氢化物(ZEAMMWESTETZTE SELBSTANORDNENDE ULTRAKLEINE PEPTIMP-POLYMER-HYDROGELE
- 专利标题: SELF-ASSEMBLED COMPOSITE ULTRASMALL PEPTIDE-POLYMER HYDROGELS
- 专利标题(中): 聚合物 - 聚合物 - 氢化物(ZEAMMWESTETZTE SELBSTANORDNENDE ULTRAKLEINE PEPTIMP-POLYMER-HYDROGELE
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申请号: EP12846222.3申请日: 2012-11-05
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公开(公告)号: EP2773696A1公开(公告)日: 2014-09-10
- 发明人: HAUSER, Charlotte , LOO, Yihua , WAN, Andrew C. A. , REITHOFER, Michael
- 申请人: Agency for Science, Technology and Research
- 申请人地址: 1 Fusionopolis Way 02-10 Connexis Singapore 138632 SG
- 专利权人: Agency for Science, Technology and Research
- 当前专利权人: Agency for Science, Technology and Research
- 当前专利权人地址: 1 Fusionopolis Way 02-10 Connexis Singapore 138632 SG
- 代理机构: Engelhard, Markus
- 优先权: SG201108178 20111104
- 国际公布: WO2013066274 20130510
- 主分类号: C08L5/00
- IPC分类号: C08L5/00 ; A61K38/06 ; A61K38/07 ; A61K38/08 ; A61L27/52 ; C08L71/02 ; C12N5/02
摘要:
The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z-(X)
m -(Y)
n -Z'
p ,wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z' is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
m -(Y)
n -Z'
p ,wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z' is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
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