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1.发明公开SELF-ASSEMBLING ULTRASHORT ALIPHATIC DEPSIPEPTIDES FOR BIOMEDICAL APPLICATIONS 审中-公开自组装超临界脂肪族去污剂用于生物医学应用
公开(公告)号：EP3265473A1
公开(公告)日：2018-01-10
申请号：EP16762071.5
申请日：2016-03-03
CPC分类号： C07K11/00 , A61K47/34 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2400/06 , A61L2430/34 , G01N2800/7095
摘要： The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of Ac-ILVaGK-NH2, where a represents lactic acid. The invention also relates to the use of these depsipeptides in formulating hydrogels, co-gels or co-hydrogels, and pharmaceutical compositions or biomedical device or surgical implants or kits comprising these depsipeptides for various therapeutic applications such as regenerative medicine, tissue regeneration and tissue re-placement.
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2.发明公开NOVEL ULTRASHORT HYDROPHOBIC PEPTIDES THAT SELF-ASSEMBLE INTO NANOFIBROUS HYDROGELS AND THEIR USES 审中-公开在NEROFASER-HYDROGELE UNDER VERWENDUNGEN中的超微量超氧化物歧化酶
公开(公告)号：EP3074415A1
公开(公告)日：2016-10-05
申请号：EP14865567.3
申请日：2014-11-28
发明人： HAUSER, Charlotte , LOO, Yihua
CPC分类号： C07K7/06 , A61K38/00 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/38 , A61L27/52 , A61L31/047 , A61L31/145 , A61L2400/06 , A61L2400/12 , A61L2430/34 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/101 , C12N5/0062 , C12N5/0068 , C12N2533/50
摘要： The present invention relates to hydrophobic peptides and/or peptidomimetics capable of forming a (nanofibrous) hydrogel and hydrogels comprising said hydrophobic peptides and/or peptidomimetics and to various uses, such as in regenerative medicine, injectable therapies, delivery of bioactive moieties, wound healing, 2D and 3D synthetic cell culture substrate, biosensor development, biofunctionalized surfaces, and biofabrication.
摘要翻译： 本发明涉及能够形成（纳米纤维）水凝胶的疏水肽和/或肽模拟物和包含所述疏水性肽和/或肽模拟物的水凝胶以及各种用途，例如再生医学，可注射疗法，递送生物活性部分，伤口愈合 ，2D和3D合成细胞培养基质，生物传感器开发，生物功能化表面和生物制造。
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3.发明公开SELF-ASSEMBLED ULTRASHORT PEPTIDES HYDROGELS FOR WOUND HEALING, SKIN CARE AND COSMETICS APPLICATIONS 审中-公开自组装超短FOR PEPTIDHYDROGELE伤口愈合，皮肤护理和化妆品应用
公开(公告)号：EP2938626A1
公开(公告)日：2015-11-04
申请号：EP13869801.4
申请日：2013-12-31
发明人： HAUSER, Charlotte , LOO, Yihua
CPC分类号： C07K5/06034 , A61K38/00 , C07K5/06026 , C07K5/0806 , C07K5/0808 , C07K5/1008 , C07K5/101 , C07K7/06
摘要： The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear peptide/peptoid is capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water, and forming a hydrogel. These peptides/peptoids include short amphiphilic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such peptides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly. A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, tissue regeneration, wound healing and release of bioactive moieties (including cells, nucleic acids, anti-microbials, micro-/nanoparticles, cosmetic agents and small molecule therapeutics), as well as for providing mechanical support for damaged or missing tissues. Such hydrogels can also be formed in situ, wherein the gelation process occurs within the body following the injection of a peptide solution. Such hydrogels, which are rigid, biocompatible and entrap up to 99.9% of water, are also well suited for applications utilizing electronic devices.
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4.发明公开SELF-ASSEMBLING PEPTIDES, PEPTIDOMIMETICS AND PEPTIDIC CONJUGATES AS BUILDING BLOCKS FOR BIOFABRICATION AND PRINTING 审中-公开SELBSTANORDNENDE PEPTIDE，PEPTIDOMIMETIKA UND PEPTIDISCHE KONJUGATE ALS BAUSTEINEFÜRBIOFABRIKATION UND BEDRUCKUNG
公开(公告)号：EP3074416A1
公开(公告)日：2016-10-05
申请号：EP14866446.9
申请日：2014-12-01
发明人： HAUSER, Charlotte , LOO, Yihua
CPC分类号： A61L27/52 , A61K38/06 , A61K38/07 , A61K38/08 , A61L27/3834 , A61L27/50 , A61L27/54 , A61L2400/06 , A61L2430/34 , B33Y10/00 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/1005 , C07K5/101 , C07K7/06 , Y02A50/385 , Y02A50/411
摘要： The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydrogels and to methods for preparing continuous fibres and to methods for obtaining multi-cellular constructs with defined, precise geometrics. The present invention further relates to various uses of such hydrogels for obtaining mini-hydrogel arrays and 3D organoid structures or 3D macromolecular biological constructs.
摘要翻译： 本发明涉及在生物制造中能够自组装和形成（纳米纤维）水凝胶的肽，拟肽和/或肽模拟物的用途。 本发明还涉及制备水凝胶的方法和制备连续纤维的方法以及获得具有确定的精确几何的多细胞构建体的方法。 本发明还涉及这种水凝胶用于获得微型水凝胶阵列和3D有机体结构或3D大分子生物构建体的各种用途。
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5.发明公开SELF-ASSEMBLED COMPOSITE ULTRASMALL PEPTIDE-POLYMER HYDROGELS 有权聚合物 - 聚合物 - 氢化物（ZEAMMWESTETZTE SELBSTANORDNENDE ULTRAKLEINE PEPTIMP-POLYMER-HYDROGELE
公开(公告)号：EP2773696A1
公开(公告)日：2014-09-10
申请号：EP12846222.3
申请日：2012-11-05
CPC分类号： A61K47/36 , A61K31/7088 , A61K35/28 , A61K35/51 , A61K35/545 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/1825 , A61K38/19 , A61K47/183 , A61K47/48215 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L26/0095 , A61L27/26 , A61L27/3834 , A61L27/48 , A61L27/52 , A61L27/54 , C08L5/00 , C08L5/04 , C08L5/08 , C08L5/10 , C08L5/16 , C08L71/02 , C08L89/00 , C12N5/0068 , C12N15/113 , C12N2310/11 , C12N2320/32 , C12N2533/30 , C12N2533/50 , C12N2533/72
摘要： The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z-(X)
m -(Y)
n -Z'
p ,wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z' is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.摘要翻译： 本发明涉及包含至少一种非肽聚合物和至少一种具有以下通式的肽的复合水凝胶：Z-（X）m-（Y）n-Z'p，其中Z是N-末端保护基 ; X在每次出现时独立地选自脂族氨基酸，脂族氨基酸衍生物和甘氨酸; Y在每次出现时独立地选自极性氨基酸和极性氨基酸衍生物; Z'是C端保护基; m是选自2至6的整数; n选自1或2; 本发明还涉及制备复合水凝胶的方法，其中使用复合水凝胶来递送药物和其它生物活性剂/部分，作为促进组织再生的植入物或可注射剂 ，以及作为伤口愈合的局部用药。 本发明还涉及包含复合水凝胶的装置和药物或化妆品组合物以及复合水凝胶的医疗用途。
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公开(公告)号：EP3921330A1
公开(公告)日：2021-12-15
申请号：EP20751861.4
申请日：2020-02-07
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公开(公告)号：EP2773696B1
公开(公告)日：2017-07-26
申请号：EP12846222.3
申请日：2012-11-05
CPC分类号： A61K47/36 , A61K31/7088 , A61K35/28 , A61K35/51 , A61K35/545 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/1825 , A61K38/19 , A61K47/183 , A61K47/48215 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L26/0095 , A61L27/26 , A61L27/3834 , A61L27/48 , A61L27/52 , A61L27/54 , C08L5/00 , C08L5/04 , C08L5/08 , C08L5/10 , C08L5/16 , C08L71/02 , C08L89/00 , C12N5/0068 , C12N15/113 , C12N2310/11 , C12N2320/32 , C12N2533/30 , C12N2533/50 , C12N2533/72
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