发明公开
EP2796875A1 Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis
有权
特异于Sektretom一个Chondrozyts蛋白质为乳腺癌转移的治疗抑制剂
- 专利标题： Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis
- 专利标题（中）： 特异于Sektretom一个Chondrozyts蛋白质为乳腺癌转移的治疗抑制剂
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申请号： EP13164922.0申请日： 2013-04-23
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公开(公告)号： EP2796875A1公开(公告)日： 2014-10-29
- 发明人: Shastri, Prasad , Christensen, Jon
- 申请人： Albert-Ludwigs-Universität Freiburg
- 申请人地址： Fahnenbergplatz 79098 Freiburg DE
- 专利权人： Albert-Ludwigs-Universität Freiburg
- 当前专利权人： Albert-Ludwigs-Universität Freiburg
- 当前专利权人地址： Fahnenbergplatz 79098 Freiburg DE
- 代理机构： Krauss, Jan
- 主分类号： G01N33/574
- IPC分类号： G01N33/574
摘要：
The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.
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