公开(公告)号：EP2796875B8

公开(公告)日：2020-08-19

申请号：EP13164922.0

申请日：2013-04-23

申请人： Albert-Ludwigs-Universität Freiburg

发明人： Shastri, Prasad ,  Christensen, Jon

IPC分类号： G01N33/574

公开(公告)号：EP2796875B1

公开(公告)日：2019-03-27

申请号：EP13164922.0

申请日：2013-04-23

申请人： Albert-Ludwigs-Universität Freiburg

发明人： Shastri, Prasad ,  Christensen, Jon

IPC分类号： G01N33/574

摘要： The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.

公开(公告)号：EP2796875A1

公开(公告)日：2014-10-29

申请号：EP13164922.0

申请日：2013-04-23

申请人： Albert-Ludwigs-Universität Freiburg

发明人： Shastri, Prasad ,  Christensen, Jon

IPC分类号： G01N33/574

摘要： The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.

摘要翻译： 本发明涉及一种用于识别基于筛选与蛋白质确实乳腺癌转移的抑制剂是特异性的软骨细胞的分泌物，细胞因子优选和/或趋化因子。 的配体所识别导致的迁移和/或乳腺癌细胞和/或减少乳腺癌转移的数量和/或大小的的再分化的降低。 本发明进一步涉及一种用于检测乳腺癌转移，包括检测至少一种蛋白的步骤做了方法是特异性的软骨细胞的分泌物，以及用于在有需要的患者中治疗和/或预防乳癌转移的方法 物，所述方法包括给予有效量的用于一个蛋白的至少一个配位体中的确实的步骤是特异于软骨细胞向需要所述患者组成的分泌蛋白质。