公开(公告)号：EP4500175A1

公开(公告)日：2025-02-05

申请号：EP23716486.8

申请日：2023-03-31

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： NAZARENKO, Irina ,  WILHELM, Konrad ,  SCHULTZE-SEEMANN, Wolfgang ,  PANIUSHKINA, Liliia

IPC: G01N33/50 ,  G01N33/574

公开(公告)号：EP4464318A1

公开(公告)日：2024-11-20

申请号：EP23174298.2

申请日：2023-05-19

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： Zeiser, Robert

IPC: A61K31/4184 ,  A61K31/19 ,  A61K31/352 ,  A61K31/365 ,  A61K31/5377 ,  A61K39/00 ,  C07K14/725 ,  A61P25/00 ,  A61P35/02

Abstract: The invention relates in a first aspect to a transforming growth factor-β-activated kinase-1 (TAK1) inhibitor for use in the treatment and/or prevention of a neuroinflammatory disorder, wherein the is preferably a T-cell induced microglia-mediated neuroinflammation. The invention relates in another aspect to a method for inhibiting microglia activation in a mammalian subject comprising inhibition of TAK1 which inhibits (reduces severity of) neuroinflammatory disorders, toxicities of cytokine release syndrome (CRS), neurotoxicity and/or neurocognitive defects. In another aspect the present invention relates to an inhibitor of microglial activation for use in the treatment of CAR T ICANS. In a further aspect the present invention relates to a method of treatment of a mammalian subject suffering a neuroinflammatory disorder, the method comprising administering a TAK1 inhibitor to said subject.

公开(公告)号：EP4463090A1

公开(公告)日：2024-11-20

申请号：EP22844660.5

申请日：2022-12-29

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： METZGER, Marc ,  BRANDENBURG, Leonard ,  SCHLAGER, Stefan

IPC: A61B34/10 ,  A61B17/17 ,  A61C7/00 ,  B33Y80/00

公开(公告)号：EP4429547A1

公开(公告)日：2024-09-18

申请号：EP22813319.5

申请日：2022-11-08

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： WENDLER, Daniel ,  KÖRBER, Jan ,  DE DORIGO, Daniel ,  MANOLI, Yiannos

IPC: A61B5/262 ,  A61B5/293 ,  A61B5/31 ,  A61B5/00

CPC classification number: A61B5/293 ,  A61B5/262 ,  A61B5/31 ,  A61B5/6848 ,  A61B5/6868

公开(公告)号：EP4405413A1

公开(公告)日：2024-07-31

申请号：EP22786943.5

申请日：2022-09-23

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： LABORIE, Marie-Pierre ,  SIVASANKARAPILLAI, Gopakumar ,  PIZZI, Antonio

IPC: C08G71/04 ,  C09J175/12 ,  C08L75/12

CPC classification number: C08G71/04 ,  C09J175/12 ,  C08L75/12

公开(公告)号：EP4287948A1

公开(公告)日：2023-12-13

申请号：EP21802374.5

申请日：2021-11-08

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： WENDLER, Daniel ,  DE DORIGO, Daniel ,  MANOLI, Yiannos

IPC: A61B5/262 ,  A61B5/293 ,  A61B5/302 ,  A61B5/31 ,  A61B5/00

公开(公告)号：EP4228630A1

公开(公告)日：2023-08-23

申请号：EP21794528.6

申请日：2021-10-15

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： GROSS, Olaf ,  NEUWIRT, Emilia ,  JUNG, Manfred

IPC: A61K31/4245 ,  A61K31/00 ,  A61K31/17 ,  A61K31/341 ,  A61K31/47 ,  A61K31/4709 ,  A61P31/00 ,  A61P35/00 ,  A61P37/04

公开(公告)号：EP4226973A1

公开(公告)日：2023-08-16

申请号：EP22156290.3

申请日：2022-02-11

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： HÄCKER, Georg ,  HAIMOVICI, Aladin ,  WEBER, Arnim

IPC: A61P35/04 ,  G01N33/573 ,  A61P37/02 ,  C12N9/16

Abstract: The present application refers to a method of preventing or reducing metastasis of tumor cells, senescence, differentiation or inflammation wherein the caspase-activated DNAse which induces strand breaks in the genomic DNA of cells causing changes of the behavior of the cell involving aggressive growth, senescence, differentiation and metastasis and/or inflammation is inactivated.

公开(公告)号：EP4218625A1

公开(公告)日：2023-08-02

申请号：EP22154524.7

申请日：2022-02-01

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： ZGIERSKI-JOHNSTON, CALLUM ,  KOHL, Peter ,  CHLEILAT, Enaam

IPC: A61B17/22

Abstract: The invention relates to a dual catheter arrangement for reperfusion of an ischemic tissue region via a coronary vessel, comprising a primary balloon catheter having a lumen for inflation and deflation of a primary balloon disposed at a distal region of the primary balloon catheter, and at least two separate lumens both extending throughout the primary balloon catheter and open at a distal end of the primary balloon catheter, and a secondary balloon catheter having a lumen for inflation and deflation of a secondary balloon disposed at a distal region of the secondary balloon catheter and an irrigation lumen opening at a distal end of the secondary balloon catheter, which is arranged slidable within one of the lumens of the primary balloon catheter to achieve a working position in which the secondary balloon catheter continues completely through the lumen of the primary balloon catheter and extends distally beyond the primary balloon catheter. Further a system for reperfusion of an ischemic tissue region via a coronary vessel is described comprising the dual catheter arrangement.

公开(公告)号：EP4155338A1

公开(公告)日：2023-03-29

申请号：EP21198849.8

申请日：2021-09-24

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： Laborie, Marie-Pierre ,  Sivasankarapillai, Gopakumar ,  Pizzi, Antonio

IPC: C08G71/04 ,  C09J175/12 ,  C08L75/12

Abstract: A process for the manufacture of a non-isocyanate polyurethane (NIPU) composition by transesterification of a condensed tannin with a carbonate or a carbonate precursor followed by the reaction with a hardener selected from diamines and products and compositions obtained thereby.